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Michael Nikolaou

TitleProfessor
InstitutionUniversity of Houston
DepartmentChemical and Biomolecular Engineering
Address4800 Calhoun Rd
Houston TX 77004
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Eales BM, Smith J, Pouya N, Hudson CS, Tam VH, Nikolaou M. Rapid Design of Combination Antimicrobial Therapy against Acinetobacter baumannii. Comput Chem Eng. 2025 Jan; 192. PMID: 39781207; PMCID: PMC11709450.
      Citations:    
    2. Hudson CS, Smith JE, Eales BM, Nikolaou M, Tam VH. In vitro model to simulate multiple drugs with distinct elimination half-lives. Int J Antimicrob Agents. 2023 Oct; 62(4):106924. PMID: 37433386; PMCID: PMC11344907.
      Citations:    Fields:    Translation:Humans
    3. Nikolaou M, Tam VH. Rapid In Vitro Assessment of Antimicrobial Drug Effect Bridging Clinically Relevant Pharmacokinetics: A Comprehensive Methodology. Pharmaceutics. 2023 Jun 07; 15(6). PMID: 37376120; PMCID: PMC10305065.
      Citations: 1     
    4. Singh G, Orman MA, Conrad JC, Nikolaou M. Systematic design of pulse dosing to eradicate persister bacteria. PLoS Comput Biol. 2023 01; 19(1):e1010243. PMID: 36649322; PMCID: PMC9882918.
      Citations: 1     Fields:    Translation:Cells
    5. Kesisoglou I, Eales BM, Merlau PR, Tam VH, Nikolaou M. Deciphering longitudinal optical-density measurements to guide clinical dosing regimen design: A model-based approach. Comput Methods Programs Biomed. 2022 Dec; 227:107212. PMID: 36335752; PMCID: PMC10225978.
      Citations: 2     Fields:    Translation:Humans
    6. Nikolaou M. Revisiting the standard for modeling the spread of infectious diseases. Sci Rep. 2022 04 30; 12(1):7077. PMID: 35490159; PMCID: PMC9056532.
      Citations:    Fields:    Translation:HumansPHPublic Health
    7. Kesisoglou I, Tam VH, Tomaras AP, Nikolaou M. Discerning in vitro pharmacodynamics from OD measurements: A model-based approach. Comput Chem Eng. 2022 Feb; 158. PMID: 35250117; PMCID: PMC8896896.
      Citations: 5     
    8. Nikolaou M. Ziegler and Nichols meet Kermack and McKendrick: Parsimony in dynamic models for epidemiology. Comput Chem Eng. 2022 Jan; 157:107615. PMID: 34961800; PMCID: PMC8696265.
      Citations: 1     
    9. Eales BM, Hudson CS, Kesisoglou I, Wang W, Nikolaou M, Tam VH. Experimental Validation of a Mathematical Framework to Simulate Antibiotics with Distinct Half-Lives Concurrently in an In Vitro Model. Antibiotics (Basel). 2021 Oct 16; 10(10). PMID: 34680836; PMCID: PMC8532833.
      Citations: 2     
    10. Kesisoglou I, Eales BM, Ledesma KR, Merlau PR, Tam VH, Wang W, Nikolaou M. SIMULTANEOUS IN VITRO SIMULATION OF MULTIPLE ANTIMICROBIAL AGENTS WITH DIFFERENT ELIMINATION HALF-LIVES IN A PRE-CLINICAL INFECTION MODEL. Comput Chem Eng. 2021 Dec; 155. PMID: 34924641; PMCID: PMC8682276.
      Citations: 6     
    11. Kesisoglou I, Singh G, Nikolaou M. The Lambert Function Should Be in the Engineering Mathematical Toolbox. Comput Chem Eng. 2021 May; 148. PMID: 34267408; PMCID: PMC8276860.
      Citations: 4     
    12. Tam VH, Abodakpi H, Wang W, Ledesma KR, Merlau PR, Chan K, Altman R, Tran TT, Nikolaou M, Sofjan AK. Optimizing pharmacokinetics/pharmacodynamics of ?-lactam/?-lactamase inhibitor combinations against high inocula of ESBL-producing bacteria. J Antimicrob Chemother. 2021 01 01; 76(1):179-183. PMID: 33035321; PMCID: PMC7729384.
      Citations: 14     Fields:    Translation:Cells
    13. Bhagunde PR, Nikolaou M, Tam VH. Modeling Heterogeneous Bacterial Populations Exposed to Antibiotics: The Logistic-Dynamics Case. AIChE J. 2015 Aug; 61(8):2385-2393. PMID: 37206682; PMCID: PMC10195107.
      Citations: 4     
    14. Tan MW, Lye DC, Ng TM, Nikolaou M, Tam VH. Mathematical model to quantify the effects of risk factors on carbapenem-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2014 Sep; 58(9):5239-44. PMID: 24957824; PMCID: PMC4135838.
      Citations:    Fields:    Translation:HumansCells
    15. Bhagunde P, Chang KT, Hirsch EB, Ledesma KR, Nikolaou M, Tam VH. Novel modeling framework to guide design of optimal dosing strategies for ?-lactamase inhibitors. Antimicrob Agents Chemother. 2012 May; 56(5):2237-40. PMID: 22330927; PMCID: PMC3346582.
      Citations: 24     Fields:    Translation:HumansCells
    16. Guo B, Abdelraouf K, Ledesma KR, Nikolaou M, Tam VH. Predicting bacterial fitness cost associated with drug resistance. J Antimicrob Chemother. 2012 Apr; 67(4):928-32. PMID: 22232512.
      Citations: 18     Fields:    Translation:HumansCells
    17. Guo B, Abdelraouf K, Ledesma KR, Chang KT, Nikolaou M, Tam VH. Quantitative impact of neutrophils on bacterial clearance in a murine pneumonia model. Antimicrob Agents Chemother. 2011 Oct; 55(10):4601-5. PMID: 21807974; PMCID: PMC3186951.
      Citations: 17     Fields:    Translation:AnimalsCells
    18. Bhagunde P, Singh R, Ledesma KR, Chang KT, Nikolaou M, Tam VH. Modelling biphasic killing of fluoroquinolones: guiding optimal dosing regimen design. J Antimicrob Chemother. 2011 May; 66(5):1079-86. PMID: 21393141.
      Citations: 3     Fields:    Translation:HumansCells
    19. Tam VH, Nikolaou M. A novel approach to pharmacodynamic assessment of antimicrobial agents: new insights to dosing regimen design. PLoS Comput Biol. 2011 Jan 06; 7(1):e1001043. PMID: 21253559; PMCID: PMC3017105.
      Citations: 15     Fields:    
    20. Bhagunde P, Chang KT, Singh R, Singh V, Garey KW, Nikolaou M, Tam VH. Mathematical modeling to characterize the inoculum effect. Antimicrob Agents Chemother. 2010 Nov; 54(11):4739-43. PMID: 20805390; PMCID: PMC2976129.
      Citations: 9     Fields:    Translation:Cells
    21. Foster WJ, Dowla N, Joshi SY, Nikolaou M. The fluid mechanics of scleral buckling surgery for the repair of retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2010 Jan; 248(1):31-6. PMID: 19809830; PMCID: PMC2809804.
      Citations: 9     Fields:    Translation:Humans
    22. Tam VH, Ledesma KR, Vo G, Kabbara S, Lim TP, Nikolaou M. Pharmacodynamic modeling of aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: identifying dosing regimens to suppress resistance development. Antimicrob Agents Chemother. 2008 Nov; 52(11):3987-93. PMID: 18725438; PMCID: PMC2573104.
      Citations: 18     Fields:    Translation:HumansCells
    23. Tam VH, Schilling AN, Poole K, Nikolaou M. Mathematical modelling response of Pseudomonas aeruginosa to meropenem. J Antimicrob Chemother. 2007 Dec; 60(6):1302-9. PMID: 17913722.
      Citations: 14     Fields:    Translation:HumansCells
    24. Nikolaou M, Schilling AN, Vo G, Chang KT, Tam VH. Modeling of microbial population responses to time-periodic concentrations of antimicrobial agents. Ann Biomed Eng. 2007 Aug; 35(8):1458-70. PMID: 17431788.
      Citations: 11     Fields:    Translation:Cells
    25. Nikolaou M, Tam VH. A new modeling approach to the effect of antimicrobial agents on heterogeneous microbial populations. J Math Biol. 2006 Feb; 52(2):154-82. PMID: 16195922.
      Citations: 16     Fields:    Translation:Cells
    26. Tam VH, Schilling AN, Nikolaou M. Modelling time-kill studies to discern the pharmacodynamics of meropenem. J Antimicrob Chemother. 2005 May; 55(5):699-706. PMID: 15772138.
      Citations: 49     Fields:    Translation:HumansCells
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