Zhang, Ruiwen
first name: Ruiwen
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selected publications: Authorship 9088
selected publications: Authorship 9089
selected publications: Authorship 9090
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selected publications: Authorship 9093
selected publications: Authorship 9095
selected publications: Authorship 9096
selected publications: Authorship 9098
selected publications: Authorship 9097
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selected publications: Authorship 9100
selected publications: Authorship 9101
selected publications: Authorship 9102
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selected publications: Authorship 9108
selected publications: Authorship 9105
selected publications: Authorship 9110
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selected publications: Authorship 9115
selected publications: Authorship 9112
selected publications: Authorship 9113
selected publications: Authorship 9116
selected publications: Authorship 9114
selected publications: Authorship 9117
research areas: Proto-Oncogene Proteins c-mdm2
research areas: Molecular Targeted Therapy
research areas: Antineoplastic Agents
research areas: NFATC Transcription Factors
research areas: Tumor Suppressor Protein p53
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NFATC Transcription Factors
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Biology and Biochemistry
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Pharmacological and Pharmaceutical Sciences
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Pharmacy Practice and Translational Research
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Hu, Ming
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Trivedi, Meghana
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Wang, Wei
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Biochemistry
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Nat Sciences & Math, Col of
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Lin, Chin-Yo
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Molecular Targeted Therapy
MeSH DescriptorUI: D058990
MeSH semantic group name: Procedures
number of authors: 13
number of publications: 36
uniqueness weight: 0.958509
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MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future.
PubMed Identifier: 38697854
author list: Wang W, Albadari N, Du Y, Fowler JF, Sang HT, Xian W, McKeon F, Li W, Zhou J, Zhang R
published in: Pharmacological reviews
information resource reference: MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future. Pharmacol Rev. 2024 May 02; 76(3):414-453.
journal title abbreviation: Pharmacol Rev
publication date: 2024-05-02T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular targeting therapies for neuroblastoma: Progress and challenges.
PubMed Identifier: 33155698
author list: Zafar A, Wang W, Liu G, Wang X, Xian W, McKeon F, Foster J, Zhou J, Zhang R
published in: Medicinal research reviews
information resource reference: Molecular targeting therapies for neuroblastoma: Progress and challenges. Med Res Rev. 2021 03; 41(2):961-1021.
journal title abbreviation: Med Res Rev
publication date: 2020-11-06T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope.
PubMed Identifier: 33007410
author list: Zafar A, Wang W, Liu G, Xian W, McKeon F, Zhou J, Zhang R
published in: Cancer letters
information resource reference: Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope. Cancer Lett. 2021 01 01; 496:16-29.
journal title abbreviation: Cancer Lett
publication date: 2020-09-29T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Antineoplastic Agents
MeSH DescriptorUI: D000970
MeSH semantic group name: Chemicals & Drugs
number of authors: 33
number of publications: 72
uniqueness weight: 0.895366
type: Concept

University of Houston
type: Organization

Authorship 9087
type: Authorship
author rank in publication: 8
linked author: Zhang, Ruiwen
linked information resource: Dual inhibitor of MDM2 and NFAT1 for experimental therapy of breast cancer: in vitro and in vivo anticancer activities and newly discovered effects on cancer metabolic pathways.

Authorship 9088
type: Authorship
author rank in publication: 1
linked author: Zhang, Ruiwen
linked information resource: Future Cancer Drug Discovery Is Now.

Authorship 9089
type: Authorship
author rank in publication: 10
linked author: Zhang, Ruiwen
linked information resource: MDM2 Inhibitors for Cancer Therapy: The Past, Present, and Future.

Authorship 9090
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Targeting the MYCN-MDM2 pathways for cancer therapy: Are they druggable?

Authorship 9091
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Structural studies of antitumor compounds that target the RING domain of MDM2.

Authorship 9092
type: Authorship
author rank in publication: 10
linked author: Zhang, Ruiwen
linked information resource: Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.

Authorship 9093
type: Authorship
author rank in publication: 5
linked author: Zhang, Ruiwen
linked information resource: Genomic Space of MGMT in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression.

Authorship 9094
type: Authorship
author rank in publication: 10
linked author: Zhang, Ruiwen
linked information resource: Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity.

Authorship 9095
type: Authorship
author rank in publication: 11
linked author: Zhang, Ruiwen
linked information resource: Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action.

Authorship 9096
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Molecular targeting therapies for neuroblastoma: Progress and challenges.

Authorship 9097
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer.

Authorship 9098
type: Authorship
author rank in publication: 7
linked author: Zhang, Ruiwen
linked information resource: Targeting the p53-MDM2 pathway for neuroblastoma therapy: Rays of hope.

Authorship 9099
type: Authorship
author rank in publication: 12
linked author: Zhang, Ruiwen
linked information resource: JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin avß3 signaling.

Authorship 9100
type: Authorship
author rank in publication: 6
linked author: Zhang, Ruiwen
linked information resource: Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action.

Authorship 9101
type: Authorship
author rank in publication: 4
linked author: Zhang, Ruiwen
linked information resource: Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy.

Authorship 9102
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Corrigendum to "A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance" [Genes Dis 694 (2019) 419-430].

Authorship 9103
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance.

Authorship 9104
type: Authorship
author rank in publication: 7
linked author: Zhang, Ruiwen
linked information resource: Targeting MDM2 for novel molecular therapy: Beyond oncology.

Authorship 9105
type: Authorship
author rank in publication: 4
linked author: Zhang, Ruiwen
linked information resource: QSAR Studies of New Pyrido[3,4-b]indole Derivatives as Inhibitors of Colon and Pancreatic Cancer Cell Proliferation.

Authorship 9106
type: Authorship
author rank in publication: 4
linked author: Zhang, Ruiwen
linked information resource: Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging.

Authorship 9107
type: Authorship
author rank in publication: 10
linked author: Zhang, Ruiwen
linked information resource: MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53.

Authorship 9108
type: Authorship
author rank in publication: 1
linked author: Zhang, Ruiwen
linked information resource: Preface.

Authorship 9109
type: Authorship
author rank in publication: 6
linked author: Zhang, Ruiwen
linked information resource: Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine.

Authorship 9110
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy.

Authorship 9111
type: Authorship
author rank in publication: 9
linked author: Zhang, Ruiwen
linked information resource: Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms.

Authorship 9112
type: Authorship
author rank in publication: 1
linked author: Zhang, Ruiwen
linked information resource: Preface.

Authorship 9113
type: Authorship
author rank in publication: 4
linked author: Zhang, Ruiwen
linked information resource: Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts.

Authorship 9114
type: Authorship
author rank in publication: 12
linked author: Zhang, Ruiwen
linked information resource: Dihydroartemisinin selectively inhibits PDGFRa-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRa protein.

Authorship 9115
type: Authorship
author rank in publication: 6
linked author: Zhang, Ruiwen
linked information resource: Inhibiting ?-Catenin by ?-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy.

Authorship 9116
type: Authorship
author rank in publication: 5
linked author: Zhang, Ruiwen
linked information resource: Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen.

Authorship 9117
type: Authorship
author rank in publication: 3
linked author: Zhang, Ruiwen
linked information resource: Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway.

Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy.
PubMed Identifier: 30217928
author list: Wang W, Qin JJ, Voruganti S, Nijampatnam B, Velu SE, Ruan KH, Hu M, Zhou J, Zhang R
published in: Cancer research
information resource reference: Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy. Cancer Res. 2018 10 01; 78(19):5656-5667.
journal title abbreviation: Cancer Res
publication date: 2018-09-14T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Dual inhibitor of MDM2 and NFAT1 for experimental therapy of breast cancer: in vitro and in vivo anticancer activities and newly discovered effects on cancer metabolic pathways.
PubMed Identifier: 40046748
author list: Wang W, Aguilar M, Datta S, Alley A, Tadesse M, Wang X, Gao X, Zhang R
published in: Frontiers in pharmacology
information resource reference: Dual inhibitor of MDM2 and NFAT1 for experimental therapy of breast cancer: in vitro and in vivo anticancer activities and newly discovered effects on cancer metabolic pathways. Front Pharmacol. 2025; 16:1531667.
journal title abbreviation: Front Pharmacol
publication date: 2025-02-19T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting the MYCN-MDM2 pathways for cancer therapy: Are they druggable?
PubMed Identifier: 39802403
author list: Wang W, Du Y, Datta S, Fowler JF, Sang HT, Albadari N, Li W, Foster J, Zhang R
published in: Genes & diseases
information resource reference: Targeting the MYCN-MDM2 pathways for cancer therapy: Are they druggable? Genes Dis. 2025 Mar; 12(2):101156.
journal title abbreviation: Genes Dis
publication date: 2023-10-27T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural studies of antitumor compounds that target the RING domain of MDM2.
PubMed Identifier: 35900024
author list: Terrell JR, Tang S, Faniyi OO, Jeong IH, Yin J, Nijampatnam B, Velu SE, Wang W, Zhang R, Luo M
published in: Protein science : a publication of the Protein Society
information resource reference: Structural studies of antitumor compounds that target the RING domain of MDM2. Protein Sci. 2022 Aug; 31(8):e4367.
journal title abbreviation: Protein Sci
publication date: 2022-08-01T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth.
PubMed Identifier: 34218269
author list: Kaluz S, Zhang Q, Kuranaga Y, Yang H, Osuka S, Bhattacharya D, Devi NS, Mun J, Wang W, Zhang R, Goodman MM, Grossniklaus HE, Van Meir EG
published in: Oncogene
information resource reference: Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth. Oncogene. 2021 Aug; 40(33):5182-5191.
journal title abbreviation: Oncogene
publication date: 2021-07-03T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Genomic Space of MGMT in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression.
PubMed Identifier: 33801310
author list: Ibrahim Al-Obaide MA, Arutla V, Bacolod MD, Wang W, Zhang R, Srivenugopal KS
published in: International journal of molecular sciences
information resource reference: Genomic Space of MGMT in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression. Int J Mol Sci. 2021 Mar 02; 22(5).
journal title abbreviation: Int J Mol Sci
publication date: 2021-03-02T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action.
PubMed Identifier: 33291373
author list: Wang W, Wang X, Rajaei M, Youn JY, Zafar A, Deokar H, Buolamwini JK, Yang J, Foster JH, Zhou J, Zhang R
published in: Cancers
information resource reference: Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action. Cancers (Basel). 2020 Dec 05; 12(12).
journal title abbreviation: Cancers (Basel)
publication date: 2020-12-05T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer.
PubMed Identifier: 33039722
author list: Ashraf-Uz-Zaman M, Shahi S, Akwii R, Sajib MS, Farshbaf MJ, Kallem RR, Putnam W, Wang W, Zhang R, Alvina K, Trippier PC, Mikelis CM, German NA
published in: European journal of medicinal chemistry
information resource reference: Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021 Jan 01; 209:112866.
journal title abbreviation: Eur J Med Chem
publication date: 2020-09-24T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action.
PubMed Identifier: 32630235
author list: Punganuru SR, Artula V, Zhao W, Rajaei M, Deokar H, Zhang R, Buolamwini JK, Srivenugopal KS, Wang W
published in: Cells
information resource reference: Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action. Cells. 2020 Jul 01; 9(7).
journal title abbreviation: Cells
publication date: 2020-07-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy.
PubMed Identifier: 32397368
author list: Wang W, Zafar A, Rajaei M, Zhang R
published in: Cells
information resource reference: Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy. Cells. 2020 05 09; 9(5).
journal title abbreviation: Cells
publication date: 2020-05-09T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Corrigendum to "A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance" [Genes Dis 694 (2019) 419-430].
PubMed Identifier: 32181287
author list: Wang W, Hu B, Qin JJ, Cheng J, Li X, Rajaei M, Fan J, Yang XR, Zhang R
published in: Genes & diseases
information resource reference: Corrigendum to "A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance" [Genes Dis 694 (2019) 419-430]. Genes Dis. 2020 03; 7(1):160-161.
journal title abbreviation: Genes Dis
publication date: 2019-12-28T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance.
PubMed Identifier: 31832522
author list: Wang W, Hu B, Qin JJ, Cheng JW, Li X, Rajaei M, Fan J, Yang XR, Zhang R
published in: Genes & diseases
information resource reference: A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance. Genes Dis. 2019 Dec; 6(4):419-430.
journal title abbreviation: Genes Dis
publication date: 2019-06-19T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting MDM2 for novel molecular therapy: Beyond oncology.
PubMed Identifier: 31587329
author list: Wang W, Qin JJ, Rajaei M, Li X, Yu X, Hunt C, Zhang R
published in: Medicinal research reviews
information resource reference: Targeting MDM2 for novel molecular therapy: Beyond oncology. Med Res Rev. 2020 05; 40(3):856-880.
journal title abbreviation: Med Res Rev
publication date: 2019-10-06T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

QSAR Studies of New Pyrido[3,4-b]indole Derivatives as Inhibitors of Colon and Pancreatic Cancer Cell Proliferation.
PubMed Identifier: 31360052
author list: Deokar H, Deokar M, Wang W, Zhang R, Buolamwini JK
published in: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents
information resource reference: QSAR Studies of New Pyrido[3,4-b]indole Derivatives as Inhibitors of Colon and Pancreatic Cancer Cell Proliferation. Med Chem Res. 2018 Dec; 27(11-12):2466-2481.
journal title abbreviation: Med Chem Res
publication date: 2018-10-03T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53.
PubMed Identifier: 31181320
author list: Wang W, Cheng JW, Qin JJ, Hu B, Li X, Nijampatnam B, Velu SE, Fan J, Yang XR, Zhang R
published in: Cancer letters
information resource reference: MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53. Cancer Lett. 2019 09 10; 459:156-167.
journal title abbreviation: Cancer Lett
publication date: 2019-06-07T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine.
PubMed Identifier: 30320185
author list: Qin JJ, Li X, Hunt C, Wang W, Wang H, Zhang R
published in: Genes & diseases
information resource reference: Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine. Genes Dis. 2018 Sep; 5(3):204-219.
journal title abbreviation: Genes Dis
publication date: 2018-07-20T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms.
PubMed Identifier: 29762656
author list: Wang W, Qin JJ, Li X, Tao G, Wang Q, Wu X, Zhou J, Zi X, Zhang R
published in: Carcinogenesis
information resource reference: Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms. Carcinogenesis. 2018 07 30; 39(8):1026-1036.
journal title abbreviation: Carcinogenesis
publication date: 2018-07-30T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibiting ?-Catenin by ?-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy.
PubMed Identifier: 29387014
author list: Qin JJ, Wang W, Li X, Deokar H, Buolamwini JK, Zhang R
published in: Frontiers in pharmacology
information resource reference: Inhibiting ?-Catenin by ?-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy. Front Pharmacol. 2018; 9:5.
journal title abbreviation: Front Pharmacol
publication date: 2018-01-17T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen.
PubMed Identifier: 29311926
author list: Qin JJ, Li X, Wang W, Zi X, Zhang R
published in: Frontiers in pharmacology
information resource reference: Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen. Front Pharmacol. 2017; 8:917.
journal title abbreviation: Front Pharmacol
publication date: 2017-12-14T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway.
PubMed Identifier: 29096894
author list: Qin JJ, Wang W, Zhang R
published in: Progress in molecular biology and translational science
information resource reference: Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway. Prog Mol Biol Transl Sci. 2017; 151:195-216.
journal title abbreviation: Prog Mol Biol Transl Sci
publication date: 2017-08-31T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Future Cancer Drug Discovery Is Now.
PubMed Identifier: 39882701
author list: Zhang R
published in: Current cancer drug targets
information resource reference: Future Cancer Drug Discovery Is Now. Curr Cancer Drug Targets. 2025; 25(1):1-2.
journal title abbreviation: Curr Cancer Drug Targets
publication date: 2025-01-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity.
PubMed Identifier: 33766692
author list: Zu Y, Zhao L, Hao L, Mechref Y, Zabet-Moghaddam M, Keyel PA, Abbasi M, Wu D, Dawson JA, Zhang R, Nie S, Moustaid-Moussa N, Kolonin MG, Daquinag AC, Brandi L, Warraich I, San Francisco SK, Sun X, Fan Z, Wang S
published in: Journal of controlled release : official journal of the Controlled Release Society
information resource reference: Browning white adipose tissue using adipose stromal cell-targeted resveratrol-loaded nanoparticles for combating obesity. J Control Release. 2021 May 10; 333:339-351.
journal title abbreviation: J Control Release
publication date: 2021-03-23T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin avß3 signaling.
PubMed Identifier: 32724456
author list: Cui J, Shu C, Xu J, Chen D, Li J, Ding K, Chen M, Li A, He J, Shu Y, Yang L, Zhang R, Zhou J
published in: Theranostics
information resource reference: JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin avß3 signaling. Theranostics. 2020; 10(18):8036-8050.
journal title abbreviation: Theranostics
publication date: 2020-07-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging.
PubMed Identifier: 31189950
author list: Punganuru SR, Madala HR, Arutla V, Zhang R, Srivenugopal KS
published in: Scientific reports
information resource reference: Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging. Sci Rep. 2019 Jun 12; 9(1):8577.
journal title abbreviation: Sci Rep
publication date: 2019-06-12T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Preface.
PubMed Identifier: 30672408
author list: Zhang R
published in: Current cancer drug targets
information resource reference: Preface. Curr Cancer Drug Targets. 2019; 19(1):2.
journal title abbreviation: Curr Cancer Drug Targets
publication date: 2019-01-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Preface.
PubMed Identifier: 29517469
author list: Zhang R
published in: Current cancer drug targets
information resource reference: Preface. Curr Cancer Drug Targets. 2018; 18(1):2.
journal title abbreviation: Curr Cancer Drug Targets
publication date: 2018-01-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts.
PubMed Identifier: 29423059
author list: Madala HR, Punganuru SR, Ali-Osman F, Zhang R, Srivenugopal KS
published in: Oncotarget
information resource reference: Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts. Oncotarget. 2018 Jan 09; 9(3):3459-3482.
journal title abbreviation: Oncotarget
publication date: 2017-12-15T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Dihydroartemisinin selectively inhibits PDGFRa-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRa protein.
PubMed Identifier: 29387451
author list: Li X, Ba Q, Liu Y, Yue Q, Chen P, Li J, Zhang H, Ying H, Ding Q, Song H, Liu H, Zhang R, Wang H
published in: Cell discovery
information resource reference: Dihydroartemisinin selectively inhibits PDGFRa-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRa protein. Cell Discov. 2017; 3:17042.
journal title abbreviation: Cell Discov
publication date: 2017-11-21T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel Small Molecule MDM2 Inhibitors for Pancreatic Cancer Therapy
end date: 2021-02-28
grant awarded by: NIH
principal investigator name: ZHANG, RUIWEN
start date: 2014-04-01
type: Agreement
type: Grant
sponsor award id: R01CA186662

MDM2 ONCOGENE AS A TARGET FOR MODULATING CANCER THERAPY
end date: 2004-03-31
grant awarded by: NIH
principal investigator name: ZHANG, RUIWEN
start date: 1999-04-07
type: Agreement
type: Grant
sponsor award id: R01CA080698

MDM2 AS A NEGATIVE REGULATOR OF P21 WAF1/CIP1
end date: 2014-08-31
grant awarded by: NIH
principal investigator name: ZHANG, RUIWEN
start date: 2005-01-01
type: Agreement
type: Grant
sponsor award id: R01CA112029

Dietary Chemopreventive Components/Oncogene Interaction and Cancer
end date: 2014-05-31
grant awarded by: NIH
principal investigator name: ZHANG, RUIWEN
start date: 2007-08-01
type: Agreement
type: Grant
sponsor award id: R01CA121211

Novel NFAT1-MDM2 inhibitor for Breast Cancer Therapy
end date: 2022-08-31
grant awarded by: NIH
principal investigator name: ZHANG, RUIWEN
start date: 2017-09-04
type: Agreement
type: Grant
sponsor award id: R01CA214019

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Zhang, Ruiwen
contributes to: MDM2 ONCOGENE AS A TARGET FOR MODULATING CANCER THERAPY

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Zhang, Ruiwen
contributes to: Dietary Chemopreventive Components/Oncogene Interaction and Cancer

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Zhang, Ruiwen
contributes to: Novel NFAT1-MDM2 inhibitor for Breast Cancer Therapy

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Zhang, Ruiwen
contributes to: MDM2 AS A NEGATIVE REGULATOR OF P21 WAF1/CIP1

Principal Investigator
type: Researcher Role
type: Role
researcher role of: Zhang, Ruiwen
contributes to: Novel Small Molecule MDM2 Inhibitors for Pancreatic Cancer Therapy

Assistant Professor
is primary position: true
position in department: Biology and Biochemistry
position in division: Biochemistry
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HR job title: Assistant Professor
position in organization: University of Houston

Professor
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position in organization: University of Houston

Professor
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position in department: Biology and Biochemistry
position in division: Cell and Molecular Biology
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HR job title: Professor
position in organization: University of Houston

Associate Professor
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position in department: Biology and Biochemistry
position in division: Nat Sciences & Math, Col of
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position in organization: University of Houston

Professor
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position in department: Pharmacological and Pharmaceutical Sciences
position in division: College of Pharmacy
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HR job title: Professor
position in organization: University of Houston

Professor
is primary position: true
position in department: Pharmacological and Pharmaceutical Sciences
position in division: College of Pharmacy
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Houston

Assistant Professor
is primary position: true
position in department: Pharmacological and Pharmaceutical Sciences
position in division: College of Pharmacy
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type: Position
HR job title: Assistant Professor
position in organization: University of Houston

Professor
is primary position: true
position in department: Pharmacy Practice and Translational Research
position in division: College of Pharmacy
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Houston

Tumor Suppressor Protein p53
MeSH DescriptorUI: D016159
MeSH semantic group name: Chemicals & Drugs
number of authors: 11
number of publications: 30
uniqueness weight: 0.965807
type: Concept

Proto-Oncogene Proteins c-mdm2
MeSH DescriptorUI: D051736
MeSH semantic group name: Chemicals & Drugs
number of authors: 6
number of publications: 26
uniqueness weight: 0.941843
type: Concept