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research areas: Orphan Nuclear Receptors
research areas: Breast Neoplasms
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Authorship 2713
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linked author: Lin, Chin-Yo
linked information resource: Liver X Receptor Ligand GAC0001E5 Downregulates Antioxidant Capacity and ERBB2/HER2 Expression in HER2-Positive Breast Cancer Cells.

Authorship 2714
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author rank in publication: 6
linked author: Lin, Chin-Yo
linked information resource: Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells.

Authorship 2715
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author rank in publication: 4
linked author: Lin, Chin-Yo
linked information resource: Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein.

Authorship 2716
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author rank in publication: 8
linked author: Lin, Chin-Yo
linked information resource: Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells.

Authorship 2717
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linked author: Lin, Chin-Yo
linked information resource: Genes Associated with Calcium Signaling are Involved in Alcohol-Induced Breast Cancer Growth.

Authorship 2718
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linked information resource: Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer.

Authorship 2719
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author rank in publication: 4
linked author: Lin, Chin-Yo
linked information resource: Estrogen receptor ? exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity.

Authorship 2720
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author rank in publication: 12
linked author: Lin, Chin-Yo
linked information resource: Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.

Authorship 2721
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author rank in publication: 16
linked author: Lin, Chin-Yo
linked information resource: Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

Authorship 2722
type: Authorship
author rank in publication: 1
linked author: Lin, Chin-Yo
linked information resource: Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells.

Authorship 2723
type: Authorship
author rank in publication: 8
linked author: Lin, Chin-Yo
linked information resource: 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.

Authorship 2724
type: Authorship
author rank in publication: 1
linked author: Lin, Chin-Yo
linked information resource: The emerging roles of liver X receptors and their ligands in cancer.

Authorship 2725
type: Authorship
author rank in publication: 11
linked author: Lin, Chin-Yo
linked information resource: Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells.

Authorship 2726
type: Authorship
author rank in publication: 1
linked author: Lin, Chin-Yo
linked information resource: Targeting liver X receptors in cancer therapeutics.

Authorship 2727
type: Authorship
author rank in publication: 4
linked author: Lin, Chin-Yo
linked information resource: The role of genetics in estrogen responses: a critical piece of an intricate puzzle.

Authorship 2728
type: Authorship
author rank in publication: 22
linked author: Lin, Chin-Yo
linked information resource: Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.

Authorship 2729
type: Authorship
author rank in publication: 3
linked author: Lin, Chin-Yo
linked information resource: Estrogen receptor signaling during vertebrate development.

Authorship 2730
type: Authorship
author rank in publication: 7
linked author: Lin, Chin-Yo
linked information resource: Genetic control of ductal morphology, estrogen-induced ductal growth, and gene expression in female mouse mammary gland.

Authorship 2731
type: Authorship
author rank in publication: 2
linked author: Lin, Chin-Yo
linked information resource: Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.

Authorship 2732
type: Authorship
author rank in publication: 3
linked author: Lin, Chin-Yo
linked information resource: Estrogen receptor alpha: molecular mechanisms and emerging insights.

Authorship 2733
type: Authorship
author rank in publication: 4
linked author: Lin, Chin-Yo
linked information resource: MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer.

Liver X Receptor Ligand GAC0001E5 Downregulates Antioxidant Capacity and ERBB2/HER2 Expression in HER2-Positive Breast Cancer Cells.
PubMed Identifier: 38730603
author list: Premaratne A, Basu S, Bagchi A, Zhou T, Feng Q, Lin CY
published in: Cancers
information resource reference: Liver X Receptor Ligand GAC0001E5 Downregulates Antioxidant Capacity and ERBB2/HER2 Expression in HER2-Positive Breast Cancer Cells. Cancers (Basel). 2024 Apr 25; 16(9).
journal title abbreviation: Cancers (Basel)
publication date: 2024-04-25T00:00:00
year: 2024
type: Academic Article
type: Article
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Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells.
PubMed Identifier: 36830714
author list: Premaratne A, Ho C, Basu S, Khan AF, Bawa-Khalfe T, Lin CY
published in: Biomolecules
information resource reference: Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells. Biomolecules. 2023 02 10; 13(2).
journal title abbreviation: Biomolecules
publication date: 2023-02-10T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein.
PubMed Identifier: 33800513
author list: Lee SA, Ho C, Troxler M, Lin CY, Chung SH
published in: Viruses
information resource reference: Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein. Viruses. 2021 03 08; 13(3).
journal title abbreviation: Viruses
publication date: 2021-03-08T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells.
PubMed Identifier: 33348693
author list: Srivastava S, Widmann S, Ho C, Nguyen D, Nguyen A, Premaratne A, Gustafsson J?, Lin CY
published in: International journal of molecular sciences
information resource reference: Novel Liver X Receptor Ligand GAC0001E5 Disrupts Glutamine Metabolism and Induces Oxidative Stress in Pancreatic Cancer Cells. Int J Mol Sci. 2020 Dec 17; 21(24).
journal title abbreviation: Int J Mol Sci
publication date: 2020-12-17T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Genes Associated with Calcium Signaling are Involved in Alcohol-Induced Breast Cancer Growth.
PubMed Identifier: 33222221
author list: Ho C, Lin CY
published in: Alcoholism, clinical and experimental research
information resource reference: Genes Associated with Calcium Signaling are Involved in Alcohol-Induced Breast Cancer Growth. Alcohol Clin Exp Res. 2021 01; 45(1):79-91.
journal title abbreviation: Alcohol Clin Exp Res
publication date: 2020-12-26T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer.
PubMed Identifier: 33139507
author list: Park Y, Baik S, Ho C, Lin CY, Chung SH
published in: Molecular cancer research : MCR
information resource reference: Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer. Mol Cancer Res. 2021 01; 19(1):42-47.
journal title abbreviation: Mol Cancer Res
publication date: 2020-11-02T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Estrogen receptor ? exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity.
PubMed Identifier: 32413024
author list: Chaurasiya S, Widmann S, Botero C, Lin CY, Gustafsson J?, Strom AM
published in: PloS one
information resource reference: Estrogen receptor ? exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity. PLoS One. 2020; 15(5):e0226057.
journal title abbreviation: PLoS One
publication date: 2020-05-15T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling.
PubMed Identifier: 31568691
author list: Mesmar F, Dai B, Ibrahim A, Hases L, Jafferali MH, Jose Augustine J, DiLorenzo S, Kang Y, Zhao Y, Wang J, Kim M, Lin CY, Berkenstam A, Fleming J, Williams C
published in: Cancer medicine
information resource reference: Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling. Cancer Med. 2019 12; 8(18):7705-7719.
journal title abbreviation: Cancer Med
publication date: 2019-09-30T00:00:00
year: 2019
type: Academic Article
type: Article
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Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.
PubMed Identifier: 28306507
author list: Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, Lin CY, Frasor J, Nettles KW, Glass CK
published in: Molecular cell
information resource reference: Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Mol Cell. 2017 Mar 16; 65(6):1122-1135.e5.
journal title abbreviation: Mol Cell
publication date: 2017-03-16T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
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Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells.
PubMed Identifier: 28003470
author list: Lin CY, Kleinbrink EL, Dachet F, Cai J, Ju D, Goldstone A, Wood EJ, Liu K, Jia H, Goustin AS, Kosir MA, Thepsuwan P, Lipovich L
published in: Open biology
information resource reference: Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells. Open Biol. 2016 12; 6(12).
journal title abbreviation: Open Biol
publication date: 2016-12-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development.
PubMed Identifier: 27671648
author list: Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, Raccosta L, Lin CY, Invernizzi F, Crocchiolo R, Doglioni C, Traversari C, Bachi A, Bernardi R, Bordignon C, Gustafsson J?, Russo V
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):E6219-E6227.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2016-09-26T00:00:00
year: 2016
type: Academic Article
type: Article
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type: Information Resource

The emerging roles of liver X receptors and their ligands in cancer.
PubMed Identifier: 26788589
author list: Lin CY, Vedin LL, Steffensen KR
published in: Expert opinion on therapeutic targets
information resource reference: The emerging roles of liver X receptors and their ligands in cancer. Expert Opin Ther Targets. 2016; 20(1):61-71.
journal title abbreviation: Expert Opin Ther Targets
publication date: 2015-08-26T00:00:00
year: 2015
type: Academic Article
type: Article
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type: Information Resource

Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells.
PubMed Identifier: 26661278
author list: Candelaria NR, Weldon R, Muthusamy S, Nguyen-Vu T, Addanki S, Yoffou PH, Karaboga H, Blessing AM, Bollu LR, Miranda RC, Lin CY
published in: PloS one
information resource reference: Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells. PLoS One. 2015; 10(12):e0145061.
journal title abbreviation: PLoS One
publication date: 2015-12-14T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting liver X receptors in cancer therapeutics.
PubMed Identifier: 25786697
author list: Lin CY, Gustafsson J?
published in: Nature reviews. Cancer
information resource reference: Targeting liver X receptors in cancer therapeutics. Nat Rev Cancer. 2015 Apr; 15(4):216-24.
journal title abbreviation: Nat Rev Cancer
publication date: 2015-03-19T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of genetics in estrogen responses: a critical piece of an intricate puzzle.
PubMed Identifier: 25212221
author list: Wall EH, Hewitt SC, Case LK, Lin CY, Korach KS, Teuscher C
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: The role of genetics in estrogen responses: a critical piece of an intricate puzzle. FASEB J. 2014 Dec; 28(12):5042-54.
journal title abbreviation: FASEB J
publication date: 2014-09-11T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.
PubMed Identifier: 25184494
author list: Candelaria NR, Addanki S, Zheng J, Nguyen-Vu T, Karaboga H, Dey P, Gabbi C, Vedin LL, Liu K, Wu W, Jonsson PK, Lin JZ, Su F, Bollu LR, Hodges SE, McElhany AL, Issazadeh MA, Fisher WE, Ittmann MM, Steffensen KR, Gustafsson J?, Lin CY
published in: PloS one
information resource reference: Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS One. 2014; 9(9):e106289.
journal title abbreviation: PLoS One
publication date: 2014-09-03T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Estrogen receptor signaling during vertebrate development.
PubMed Identifier: 24954179
author list: Bondesson M, Hao R, Lin CY, Williams C, Gustafsson J?
published in: Biochimica et biophysica acta
information resource reference: Estrogen receptor signaling during vertebrate development. Biochim Biophys Acta. 2015 Feb; 1849(2):142-51.
journal title abbreviation: Biochim Biophys Acta
publication date: 2014-06-17T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic control of ductal morphology, estrogen-induced ductal growth, and gene expression in female mouse mammary gland.
PubMed Identifier: 24708240
author list: Wall EH, Case LK, Hewitt SC, Nguyen-Vu T, Candelaria NR, Teuscher C, Lin CY
published in: Endocrinology
information resource reference: Genetic control of ductal morphology, estrogen-induced ductal growth, and gene expression in female mouse mammary gland. Endocrinology. 2014 Aug; 155(8):3025-35.
journal title abbreviation: Endocrinology
publication date: 2014-04-07T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Oestrogen receptors in breast cancer: basic mechanisms and clinical implications.
PubMed Identifier: 24222786
author list: Williams C, Lin CY
published in: Ecancermedicalscience
information resource reference: Oestrogen receptors in breast cancer: basic mechanisms and clinical implications. Ecancermedicalscience. 2013 Nov 05; 7:370.
journal title abbreviation: Ecancermedicalscience
publication date: 2013-11-05T00:00:00
year: 2013
type: Academic Article
type: Article
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Estrogen receptor alpha: molecular mechanisms and emerging insights.
PubMed Identifier: 23649536
author list: Candelaria NR, Liu K, Lin CY
published in: Journal of cellular biochemistry
information resource reference: Estrogen receptor alpha: molecular mechanisms and emerging insights. J Cell Biochem. 2013 Oct; 114(10):2203-8.
journal title abbreviation: J Cell Biochem
publication date: 2013-10-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer.
PubMed Identifier: 22562546
author list: Aydogdu E, Katchy A, Tsouko E, Lin CY, Haldos?n LA, Helguero L, Williams C
published in: Carcinogenesis
information resource reference: MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer. Carcinogenesis. 2012 Aug; 33(8):1502-11.
journal title abbreviation: Carcinogenesis
publication date: 2012-05-04T00:00:00
year: 2012
type: Academic Article
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type: Document
type: Information Resource

Antineoplastic Agents
MeSH DescriptorUI: D000970
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number of publications: 72
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Orphan Nuclear Receptors
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University of Houston
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sort order: 1
type: Position
HR job title: Professor
position in organization: University of Houston

Associate Professor
is primary position: true
position in department: Biology and Biochemistry
position in division: Nat Sciences & Math, Col of
sort order: 1
type: Position
HR job title: Associate Professor
position in organization: University of Houston

Professor
is primary position: true
position in department: Pharmacological and Pharmaceutical Sciences
position in division: College of Pharmacy
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Houston

Assistant Professor
is primary position: true
position in department: Pharmacological and Pharmaceutical Sciences
position in division: College of Pharmacy
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: University of Houston

Assistant Professor
is primary position: true
position in department: Pharmacological and Pharmaceutical Sciences
position in division: College of Pharmacy
sort order: 1
type: Position
HR job title: Assistant Professor
position in organization: University of Houston

Professor
is primary position: true
position in department: Pharmacy Practice and Translational Research
position in division: College of Pharmacy
sort order: 1
type: Position
HR job title: Professor
position in organization: University of Houston