Lupus Erythematosus, Systemic
"Lupus Erythematosus, Systemic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Descriptor ID |
D008180
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| MeSH Number(s) |
C17.300.480 C20.111.590
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lupus Erythematosus, Systemic".
Below are MeSH descriptors whose meaning is more specific than "Lupus Erythematosus, Systemic".
This graph shows the total number of publications written about "Lupus Erythematosus, Systemic" by people in this website by year, and whether "Lupus Erythematosus, Systemic" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 4 | 0 | 4 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lupus Erythematosus, Systemic" by people in Profiles.
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Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus. J Transl Med. 2025 Jan 27; 23(1):118.
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Dysregulation in keratinocytes drives systemic lupus erythematosus onset. Cell Mol Immunol. 2025 Jan; 22(1):83-96.
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2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus. Signal Transduct Target Ther. 2024 Nov 17; 9(1):323.
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IL-1ß mediated fibroblast-neutrophil crosstalk promotes inflammatory environment in skin lesions of SLE. Clin Immunol. 2024 Dec; 269:110396.
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Oxysterols contribute to immune cell recruitment in SLE skin lesions. Arthritis Res Ther. 2024 Oct 22; 26(1):181.
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Faslpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus. Clin Immunol. 2024 01; 258:109874.
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Targeting MDM2 for novel molecular therapy: Beyond oncology. Med Res Rev. 2020 05; 40(3):856-880.
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Identification of autoantibodies against transthyretin for the screening and diagnosis of rheumatoid arthritis. PLoS One. 2014; 9(4):e93905.