"Click Chemistry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
| Descriptor ID |
D057930
|
| MeSH Number(s) |
E05.197.124 J01.897.836.249.124
|
| Concept/Terms |
Click Chemistry- Click Chemistry
- Chemistries, Click
- Chemistry, Click
- Click Chemistries
- Click Chemical Techniques
- Chemical Technique, Click
- Chemical Techniques, Click
- Click Chemical Technique
- Technique, Click Chemical
- Techniques, Click Chemical
Click Chemical Reactions- Click Chemical Reactions
- Chemical Reaction, Click
- Chemical Reactions, Click
- Click Chemical Reaction
- Reaction, Click Chemical
- Reactions, Click Chemical
|
Below are MeSH descriptors whose meaning is more general than "Click Chemistry".
Below are MeSH descriptors whose meaning is more specific than "Click Chemistry".
This graph shows the total number of publications written about "Click Chemistry" by people in this website by year, and whether "Click Chemistry" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 5 | 6 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Click Chemistry" by people in Profiles.
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Modification of fluorous substrates with oligo(ethylene glycol) via "click" chemistry for long-term resistance of cell adhesion. J Colloid Interface Sci. 2015 Nov 15; 458:112-8.
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Poly(L-lysine) Interfaces via Dual Click Reactions on Surface-Bound Custom-Designed Dithiol Adsorbates. Langmuir. 2015 Jun 09; 31(22):6154-63.
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"Click" immobilization of a VEGF-mimetic peptide on decellularized endothelial extracellular matrix to enhance angiogenesis. ACS Appl Mater Interfaces. 2014 Jun 11; 6(11):8401-6.
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Immobilization of antimicrobial peptide IG-25 onto fluoropolymers via fluorous interactions and click chemistry. ACS Appl Mater Interfaces. 2013 Dec 26; 5(24):12789-93.
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Click chemistry-based functionalization on non-oxidized silicon substrates. Chem Asian J. 2011 Oct 04; 6(10):2592-605.
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Biofunctionalization of a "clickable" organic layer photochemically grafted on titanium substrates. Langmuir. 2011 Apr 19; 27(8):4848-56.
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Rapid grafting of azido-labeled oligo(ethylene glycol)s onto an alkynyl-terminated monolayer on nonoxidized silicon via microwave-assisted "click" reaction. Langmuir. 2011 Mar 15; 27(6):2437-45.
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Anaerobic conditions to reduce oxidation of proteins and to accelerate the copper-catalyzed "Click" reaction with a water-soluble bis(triazole) ligand. Chem Commun (Camb). 2011 Mar 21; 47(11):3186-8.
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"Click" immobilization on alkylated silicon substrates: model for the study of surface bound antimicrobial peptides. Chemistry. 2011 Feb 25; 17(9):2656-65.
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Localization of antimicrobial peptides on polymerized liposomes leading to their enhanced efficacy against Pseudomonas aeruginosa. Mol Biosyst. 2011 Mar; 7(3):711-3.