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Ming Hu to Animals

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This is a "connection" page, showing publications Ming Hu has written about Animals.
Ming Hu
Connection Strength
3.601
Animals
  1. Fecal SN-38 Content as a Surrogate Predictor of Intestinal SN-38 Exposure and Associated Irinotecan-induced Severe Delayed-Onset Diarrhea by a Novel Use of the Spectrofluorimetric Method. Pharm Res. 2024 Sep; 41(9):1855-1867.
    View in: PubMed
    Score: 0.141
  2. Optimized rat models better mimic patients with irinotecan-induced severe diarrhea. Toxicol Mech Methods. 2024 Jun; 34(5):572-583.
    View in: PubMed
    Score: 0.136
  3. The role of gut microbial ?-glucuronidase in drug disposition and development. Drug Discov Today. 2022 10; 27(10):103316.
    View in: PubMed
    Score: 0.122
  4. Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer. J Nat Prod. 2021 09 24; 84(9):2486-2495.
    View in: PubMed
    Score: 0.115
  5. Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats. Elife. 2021 07 01; 10.
    View in: PubMed
    Score: 0.113
  6. One-Step Transformation from Rofecoxib to a COX-2 NIR Probe for Human Cancer Tissue/Organoid Targeted Bioimaging. ACS Appl Bio Mater. 2021 03 15; 4(3):2723-2731.
    View in: PubMed
    Score: 0.111
  7. Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo. Arch Toxicol. 2020 Nov; 94(11):3737-3749.
    View in: PubMed
    Score: 0.107
  8. Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma. J Agric Food Chem. 2020 Jun 17; 68(24):6576-6587.
    View in: PubMed
    Score: 0.105
  9. Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: Application to a portal vein infusion study. Anal Biochem. 2020 07 15; 601:113723.
    View in: PubMed
    Score: 0.104
  10. Flavonoids interference in common protein assays: Effect of position and degree of hydroxyl substitution. Anal Biochem. 2020 05 15; 597:113644.
    View in: PubMed
    Score: 0.103
  11. Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc?am1137) rat with celecoxib. Inflamm Res. 2020 Jan; 69(1):131-137.
    View in: PubMed
    Score: 0.102
  12. Metabolism of Phenolic Compounds in LPS-stimulated Raw264.7 Cells Can Impact Their Anti-inflammatory efficacy: Indication of Hesperetin. J Agric Food Chem. 2018 Jun 20; 66(24):6042-6052.
    View in: PubMed
    Score: 0.092
  13. Development and validation of a sensitive LC-MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies. J Pharm Biomed Anal. 2018 Jan 30; 148:65-72.
    View in: PubMed
    Score: 0.087
  14. Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. J Pharm Biomed Anal. 2018 Jan 30; 148:42-50.
    View in: PubMed
    Score: 0.086
  15. Glucuronidation: driving factors and their impact on glucuronide disposition. Drug Metab Rev. 2017 05; 49(2):105-138.
    View in: PubMed
    Score: 0.085
  16. Transport-Glucuronidation Classification System and PBPK Modeling: New Approach To Predict the Impact of Transporters on Disposition of Glucuronides. Mol Pharm. 2017 09 05; 14(9):2884-2898.
    View in: PubMed
    Score: 0.084
  17. Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Mol Nutr Food Res. 2016 Sep; 60(9):1967-83.
    View in: PubMed
    Score: 0.080
  18. Determination of 7a-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 01; 1025:76-82.
    View in: PubMed
    Score: 0.079
  19. In?vitro glucuronidation of methyl gallate and pentagalloyl glucopyranose by liver microsomes. Drug Metab Pharmacokinet. 2016 Aug; 31(4):292-303.
    View in: PubMed
    Score: 0.079
  20. Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides. Mol Nutr Food Res. 2016 May; 60(5):1006-19.
    View in: PubMed
    Score: 0.079
  21. Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:34-41.
    View in: PubMed
    Score: 0.078
  22. Factors Influencing Oral Bioavailability of Thai Mango Seed Kernel Extract and Its Key Phenolic Principles. Molecules. 2015 Nov 30; 20(12):21254-73.
    View in: PubMed
    Score: 0.077
  23. Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Pharm Res. 2016 Mar; 33(3):590-602.
    View in: PubMed
    Score: 0.077
  24. Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 01; 1002:13-8.
    View in: PubMed
    Score: 0.075
  25. Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15; 1001:202-11.
    View in: PubMed
    Score: 0.075
  26. Determination of pharmacokinetics of chrysin and its conjugates in wild-type FVB and Bcrp1 knockout mice using a validated LC-MS/MS method. J Agric Food Chem. 2015 Mar 25; 63(11):2902-10.
    View in: PubMed
    Score: 0.073
  27. Development and validation of an UPLC-MS/MS method for the quantification of ethoxzolamide in blood, brain tissue, and bioequivalent buffers: applications to absorption, brain distribution, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 01; 986-987:54-9.
    View in: PubMed
    Score: 0.073
  28. Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium. Mol Biochem Parasitol. 2024 12; 260:111637.
    View in: PubMed
    Score: 0.035
  29. Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice. Front Immunol. 2023; 14:1196434.
    View in: PubMed
    Score: 0.034
  30. Cellular composition and circuit organization of the locus coeruleus of adult mice. Elife. 2023 02 03; 12.
    View in: PubMed
    Score: 0.032
  31. Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea. Food Chem Toxicol. 2022 Aug; 166:113246.
    View in: PubMed
    Score: 0.030
  32. SIRT1 inhibition-induced senescence as a strategy to prevent prostate cancer progression. Mol Carcinog. 2022 Jul; 61(7):702-716.
    View in: PubMed
    Score: 0.030
  33. Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11-deficient mice. J Pathol. 2021 Dec; 255(4):412-424.
    View in: PubMed
    Score: 0.029
  34. Age-and Region-Dependent Disposition of Raloxifene in Rats. Pharm Res. 2021 Aug; 38(8):1357-1367.
    View in: PubMed
    Score: 0.029
  35. A positive-negative switching LC-MS/MS method for quantification of fenoldopam and its phase II metabolites: Applications to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Aug 01; 1179:122854.
    View in: PubMed
    Score: 0.028
  36. Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs. J Med Chem. 2021 Jun 10; 64(11):7045-7059.
    View in: PubMed
    Score: 0.028
  37. UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder. Biochem Pharmacol. 2021 Aug; 190:114592.
    View in: PubMed
    Score: 0.028
  38. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
    View in: PubMed
    Score: 0.028
  39. Development and validation of ultra-high-performance liquid chromatography-mass spectrometry method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats. J Sep Sci. 2020 Dec; 43(24):4414-4423.
    View in: PubMed
    Score: 0.027
  40. Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt. Toxicol Appl Pharmacol. 2020 07 01; 398:115032.
    View in: PubMed
    Score: 0.026
  41. Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I. Cell Commun Signal. 2020 Apr 07; 18(1):58.
    View in: PubMed
    Score: 0.026
  42. Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem Pharmacol. 2020 Feb; 172:113753.
    View in: PubMed
    Score: 0.025
  43. Potential of herb-drug / herb interactions between substrates and inhibitors of UGTs derived from herbal medicines. Pharmacol Res. 2019 Dec; 150:104510.
    View in: PubMed
    Score: 0.025
  44. Metabolic profiles of Xiao Chai Hu Tang in mouse plasma, bile and urine by the UHPLC-ESI-Q-TOF/MS technique. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Oct 01; 1128:121767.
    View in: PubMed
    Score: 0.025
  45. Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide. Drug Metab Dispos. 2019 03; 47(3):203-214.
    View in: PubMed
    Score: 0.024
  46. Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Curr Cancer Drug Targets. 2019; 19(7):551-560.
    View in: PubMed
    Score: 0.024
  47. An update on polyphenol disposition via coupled metabolic pathways. Expert Opin Drug Metab Toxicol. 2019 Feb; 15(2):151-165.
    View in: PubMed
    Score: 0.024
  48. Interplay of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol. Mol Pharm. 2018 Dec 03; 15(12):5602-5614.
    View in: PubMed
    Score: 0.024
  49. Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy. Cancer Res. 2018 10 01; 78(19):5656-5667.
    View in: PubMed
    Score: 0.023
  50. Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis. J Control Release. 2018 Sep 28; 286:315-325.
    View in: PubMed
    Score: 0.023
  51. Age-related changes in hepatic expression and activity of drug metabolizing enzymes in male wild-type and breast cancer resistance protein knockout mice. Biopharm Drug Dispos. 2018 Jul; 39(7):344-353.
    View in: PubMed
    Score: 0.023
  52. Impact of diet on irinotecan toxicity in mice. Chem Biol Interact. 2018 Aug 01; 291:87-94.
    View in: PubMed
    Score: 0.023
  53. Tissue Distribution and Gender-Specific Protein Expression of Cytochrome P450 in five Mouse Genotypes with a Background of FVB. Pharm Res. 2018 Apr 10; 35(6):114.
    View in: PubMed
    Score: 0.023
  54. Simultaneous determination of tilianin and its metabolites in mice using ultra-high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. Biomed Chromatogr. 2018 Apr; 32(4).
    View in: PubMed
    Score: 0.022
  55. An LC-MS/MS method for simultaneous determination of nine steroidal saponins from Paris polyphylla var. in rat plasma and its application to pharmacokinetic study. J Pharm Biomed Anal. 2017 Oct 25; 145:675-681.
    View in: PubMed
    Score: 0.022
  56. Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice. Mol Pharm. 2017 Sep 05; 14(9):2967-2976.
    View in: PubMed
    Score: 0.022
  57. Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Biomed Chromatogr. 2017 Dec; 31(12).
    View in: PubMed
    Score: 0.022
  58. Sulfotransferases and Breast Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in Vivo. Mol Pharm. 2017 Sep 05; 14(9):2917-2929.
    View in: PubMed
    Score: 0.021
  59. Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides. Pharm Res. 2017 Jul; 34(7):1402-1415.
    View in: PubMed
    Score: 0.021
  60. High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences. Drug Metab Dispos. 2017 06; 45(6):624-634.
    View in: PubMed
    Score: 0.021
  61. Metabolic Disposition of Luteolin Is Mediated by the Interplay of UDP-Glucuronosyltransferases and Catechol-O-Methyltransferases in Rats. Drug Metab Dispos. 2017 03; 45(3):306-315.
    View in: PubMed
    Score: 0.021
  62. In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters. AAPS J. 2016 Sep; 18(5):1289-1299.
    View in: PubMed
    Score: 0.020
  63. Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer. Pharmacol Res. 2016 Sep; 111:113-125.
    View in: PubMed
    Score: 0.020
  64. Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/ß-catenin signaling. Oncotarget. 2016 May 24; 7(21):31413-28.
    View in: PubMed
    Score: 0.020
  65. Characterization of oxygenated metabolites of ginsenoside Rg1 in plasma and urine of rat. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15; 1026:75-86.
    View in: PubMed
    Score: 0.019
  66. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
    View in: PubMed
    Score: 0.019
  67. SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-?-d-Glucoside in Rats. Drug Metab Dispos. 2016 Mar; 44(3):283-96.
    View in: PubMed
    Score: 0.019
  68. Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. Biopharm Drug Dispos. 2015 Dec; 36(9):622-35.
    View in: PubMed
    Score: 0.019
  69. Simultaneous determinations of 17 marker compounds in Xiao-Chai-Hu-Tang by LC-MS/MS: Application to its pharmacokinetic studies in mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15; 1003:12-21.
    View in: PubMed
    Score: 0.019
  70. A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. J Chromatogr A. 2015 May 22; 1395:116-28.
    View in: PubMed
    Score: 0.018
  71. Characterization of oxygenated metabolites of ginsenoside Rb1 in plasma and urine of rat. J Agric Food Chem. 2015 Mar 18; 63(10):2689-700.
    View in: PubMed
    Score: 0.018
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The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.