"Thienamycins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
| Descriptor ID |
D013845
|
| MeSH Number(s) |
D02.065.589.099.124.300 D03.633.100.300.124.300
|
| Concept/Terms |
Thienamycins- Thienamycins
- Antibiotics, Thienamycin
- Thienamycin Antibiotics
|
Below are MeSH descriptors whose meaning is more general than "Thienamycins".
Below are MeSH descriptors whose meaning is more specific than "Thienamycins".
This graph shows the total number of publications written about "Thienamycins" by people in this website by year, and whether "Thienamycins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 2 | 1 | 3 |
| 2007 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thienamycins" by people in Profiles.
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Determining ?-lactam exposure threshold to suppress resistance development in Gram-negative bacteria. J Antimicrob Chemother. 2017 05 01; 72(5):1421-1428.
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Inhibition of biofilm formation by esomeprazole in Pseudomonas aeruginosa and Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug; 56(8):4360-4.
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Mathematical modelling response of Pseudomonas aeruginosa to meropenem. J Antimicrob Chemother. 2007 Dec; 60(6):1302-9.
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Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2005 Dec; 49(12):4920-7.
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A new modeling approach to the effect of antimicrobial agents on heterogeneous microbial populations. J Math Biol. 2006 Feb; 52(2):154-82.
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Modelling time-kill studies to discern the pharmacodynamics of meropenem. J Antimicrob Chemother. 2005 May; 55(5):699-706.