"Hemoglobin, Sickle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
| Descriptor ID |
D006451
|
| MeSH Number(s) |
D12.776.124.400.463.588 D12.776.422.316.762.426.588
|
| Concept/Terms |
Deoxyhemoglobin S- Deoxyhemoglobin S
- Deoxygenated Sickle Hemoglobin
- Hemoglobin, Deoxygenated Sickle
- Sickle Hemoglobin, Deoxygenated
|
Below are MeSH descriptors whose meaning is more general than "Hemoglobin, Sickle".
Below are MeSH descriptors whose meaning is more specific than "Hemoglobin, Sickle".
This graph shows the total number of publications written about "Hemoglobin, Sickle" by people in this website by year, and whether "Hemoglobin, Sickle" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hemoglobin, Sickle" by people in Profiles.
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Quantitative prediction of erythrocyte sickling for the development of advanced sickle cell therapies. Sci Adv. 2019 08; 5(8):eaax3905.
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Probing the Twisted Structure of Sickle Hemoglobin Fibers via Particle Simulations. Biophys J. 2016 05 10; 110(9):2085-93.
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A prospective newborn screening and treatment program for sickle cell anemia in Luanda, Angola. Am J Hematol. 2013 Dec; 88(12):984-9.
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Free heme and the polymerization of sickle cell hemoglobin. Biophys J. 2010 Sep 22; 99(6):1976-85.
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Free heme in micromolar amounts enhances the attraction between sickle cell hemoglobin molecules. Biopolymers. 2009 Dec; 91(12):1108-16.
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Determination of the transition-state entropy for aggregation suggests how the growth of sickle cell hemoglobin polymers can be slowed. J Mol Biol. 2008 Mar 28; 377(3):882-8.
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Sickle-cell haemoglobin polymerization: is it the primary pathogenic event of sickle-cell anaemia? Br J Haematol. 2007 Oct; 139(2):173-84.
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Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers. Biophys J. 2007 Aug 01; 93(3):902-13.
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Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin. Biophys J. 2007 Jan 01; 92(1):267-77.
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The kinetics of nucleation and growth of sickle cell hemoglobin fibers. J Mol Biol. 2007 Jan 12; 365(2):425-39.