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Mehmet Sen

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentBiology and Biochemistry
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-1448
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    R03AI139651     (SEN, MEHMET)May 7, 2018 - Apr 30, 2020
    NIH
    The atomic basis of leukocyte adhesion receptor (CD11c/CD18) activation and antagonism in solution
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Risman RA, Sen M, Tutwiler V, Hudson NE. Deconstructing fibrin(ogen) structure. J Thromb Haemost. 2025 Feb; 23(2):368-380. PMID: 39536819; PMCID: PMC11786978.
      Citations:    Fields:    
    2. Martinez-Vargas M, Courson J, Gardea L, Sen M, Yee A, Rumbaut R, Cruz MA. The impact of von Willebrand factor on fibrin formation and structure unveiled with type 3 von Willebrand disease plasma. Blood Coagul Fibrinolysis. 2024 Jul 01; 35(5):256-264. PMID: 38973517; PMCID: PMC11232922.
      Citations:    Fields:    Translation:HumansCells
    3. Huo T, Wu H, Moussa Z, Sen M, Dalton V, Wang Z. Full-length aIIb?3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure. 2024 Jul 11; 32(7):899-906.e3. PMID: 38579706; PMCID: PMC11246237.
      Citations: 3     Fields:    Translation:HumansCells
    4. Sen M. Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization. Structure. 2024 01 04; 32(1):3-5. PMID: 38181726.
      Citations: 1     Fields:    Translation:Cells
    5. Verma S, Ogata FT, Moreno IY, Prinholato da Silva C, Marforio TD, Calvaresi M, Sen M, Coulson-Thomas VJ, Gesteira TF. Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing. Ocul Surf. 2023 Oct; 30:168-178. PMID: 37742739; PMCID: PMC11092926.
      Citations: 1     Fields:    Translation:HumansAnimals
    6. Wang Z, Huo T, Wu H, Moussa Z, Sen M, Dalton V. Full-length aIIb?3 CryoEM structure reveals intact integrin initiate-activation intrinsic architecture. Res Sq. 2023 Feb 24. PMID: 36865117; PMCID: PMC9980189.
      Citations:    
    7. Pinelo JEE, Manandhar P, Popovic G, Ray K, Tasdelen MF, Nguyen Q, Iavarone AT, Offenbacher AR, Hudson NE, Sen M. Systematic mapping of the conformational landscape and dynamism of soluble fibrinogen. J Thromb Haemost. 2023 06; 21(6):1529-1543. PMID: 36746319; PMCID: PMC10407912.
      Citations: 3     Fields:    Translation:HumansCells
    8. Nandy S, Maranholkar VM, Crum M, Wasden K, Patil U, Goyal A, Vu B, Kourentzi K, Mo W, Henrickson A, Demeler B, Sen M, Willson RC. Expression and Characterization of Intein-Cyclized Trimer of Staphylococcus aureus Protein A Domain Z. Int J Mol Sci. 2023 Jan 09; 24(2). PMID: 36674796; PMCID: PMC9865183.
      Citations: 2     Fields:    Translation:HumansCells
    9. Manandhar P, Mazhar Z, Abousaway O, Aboagye C, Moussa Z, Lim D, Yu T, Byrnes J, Briggs JM, Sen M. Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin aX?2. Cell Rep. 2022 08 23; 40(8):111254. PMID: 36001965; PMCID: PMC9440770.
      Citations: 1     Fields:    Translation:Cells
    10. Jensen RK, Bajic G, Sen M, Springer TA, Vorup-Jensen T, Andersen GR. Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b. J Immunol. 2021 06 15; 206(12):3032-3042. PMID: 34117107.
      Citations: 14     Fields:    Translation:Humans
    11. Liu X, Wang YL, Wu J, Qi J, Zeng Z, Wan Q, Chen Z, Manandhar P, Cavener VS, Boyle NR, Fu X, Salazar E, Kuchipudi SV, Kapur V, Zhang X, Umetani M, Sen M, Willson RC, Chen SH, Zu Y. Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. Angew Chem Int Ed Engl. 2021 04 26; 60(18):10273-10278. PMID: 33684258; PMCID: PMC8250721.
      Citations: 50     Fields:    Translation:HumansCells
    12. Liu X, Wang YL, Wu J, Qi J, Zeng Z, Wan Q, Chen Z, Manandhar P, Cavener VS, Boyle NR, Fu X, Salazar E, Kuchipudi SV, Kapur V, Zhang X, Umetani M, Sen M, Willson RC, Chen SH, Zu Y. Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection. Angew Chem Weinheim Bergstr Ger. 2021 Apr 26; 133(18):10361-10366. PMID: 34230707; PMCID: PMC8250357.
      Citations: 7     
    13. Fannin S, Rangel J, Bodurin AP, Yu T, Mistretta B, Mali S, Gunaratne P, Bark SJ, Ebalunode JO, Khan A, Widger WR, Sen M. Functional and structural characterization of Hyp730, a highly conserved and dormancy-specific hypothetical membrane protein. Microbiologyopen. 2021 01; 10(1):e1154. PMID: 33650800; PMCID: PMC7856521.
      Citations: 1     Fields:    Translation:Cells
    14. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Cis interaction between sialylated Fc?RIIA and the aI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Nat Commun. 2018 11 29; 9(1):5058. PMID: 30498196; PMCID: PMC6265255.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    15. Hiramitsu S, Ishikawa T, Lee WR, Khan T, Crumbley C, Khwaja N, Zamanian F, Asghari A, Sen M, Zhang Y, Hawse JR, Minna JD, Umetani M. Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol. Front Endocrinol (Lausanne). 2018; 9:470. PMID: 30190703; PMCID: PMC6116707.
      Citations: 18     Fields:    
    16. Kurakula K, Koenis DS, Herzik MA, Liu Y, Craft JW, van Loenen PB, Vos M, Tran MK, Versteeg HH, Goumans MTH, Ruf W, de Vries CJM, Sen M. Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity. Haematologica. 2018 06; 103(6):1073-1082. PMID: 29545340; PMCID: PMC6058786.
      Citations: 10     Fields:    Translation:HumansCells
    17. Sen M, Koksal AC, Yuki K, Wang J, Springer TA. Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1. J Biol Chem. 2018 04 27; 293(17):6565-6577. PMID: 29507098; PMCID: PMC5925802.
      Citations: 9     Fields:    Translation:HumansCells
    18. Wilson ZS, Ahn LB, Serratelli WS, Belley MD, Lomas-Neira J, Sen M, Lefort CT. Activated ß2 Integrins Restrict Neutrophil Recruitment during Murine Acute Pseudomonal Pneumonia. Am J Respir Cell Mol Biol. 2017 May; 56(5):620-627. PMID: 28157452; PMCID: PMC5449489.
      Citations: 16     Fields:    Translation:AnimalsCells
    19. Sen M, Springer TA. Leukocyte integrin aL?2 headpiece structures: The aI domain, the pocket for the internal ligand, and concerted movements of its loops. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):2940-5. PMID: 26936951; PMCID: PMC4801256.
      Citations: 25     Fields:    Translation:HumansCells
    20. Sen M, Herzik M, Craft JW, Creath AL, Agrawal S, Ruf W, Legge GB. Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region. Open Spectrosc J. 2009 Jan 01; 3:58-64. PMID: 20076769; PMCID: PMC2805860.
      Citations: 8     
    21. Carre?o R, Li D, Sen M, Nira I, Yamakawa T, Ma Q, Legge GB. A mechanism for antibody-mediated outside-in activation of LFA-1. J Biol Chem. 2008 Apr 18; 283(16):10642-8. PMID: 18199751.
      Citations: 3     Fields:    Translation:HumansCells
    22. Sen M, Legge GB. Pactolus I-domain: functional switching of the Rossmann fold. Proteins. 2007 Aug 15; 68(3):626-35. PMID: 17523188.
      Citations: 4     Fields:    Translation:Cells
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