"Tetraspanins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large superfamily of cell surface membrane proteins characterized by their four transmembrane domains. They play a role in a variety of processes such as cellular adhesion and motility. They may be involved in the organization of cell surface MEMBRANE MICRODOMAINS that regulate the activation of LEUKOCYTES.
| Descriptor ID |
D059470
|
| MeSH Number(s) |
D12.776.543.900
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Tetraspanins".
Below are MeSH descriptors whose meaning is more specific than "Tetraspanins".
This graph shows the total number of publications written about "Tetraspanins" by people in this website by year, and whether "Tetraspanins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 2 | 3 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tetraspanins" by people in Profiles.
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The PRPH2 D2 Loop: Biochemical Insights and Implications in Disease. Adv Exp Med Biol. 2025; 1468:313-317.
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ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims. Elife. 2023 Nov 22; 12.
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Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones. Cell Mol Life Sci. 2023 Jul 19; 80(8):214.
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The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis. Adv Exp Med Biol. 2023; 1415:277-281.
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Prph2 disease mutations lead to structural and functional defects in the RPE. FASEB J. 2022 05; 36(5):e22284.
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ROM1 contributes to phenotypic heterogeneity in PRPH2-associated retinal disease. Hum Mol Genet. 2020 09 29; 29(16):2708-2722.
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Novel molecular mechanisms for Prph2-associated pattern dystrophy. FASEB J. 2020 01; 34(1):1211-1230.
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Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization. Hum Mol Genet. 2019 02 01; 28(3):459-475.
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Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation. Hum Mol Genet. 2018 10 15; 27(20):3507-3518.
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Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa. Hum Mol Genet. 2017 02 01; 26(3):509-518.