"TRPC Cation Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subgroup of TRP cation channels that contain 3-4 ANKYRIN REPEAT DOMAINS and a conserved C-terminal domain. Members are highly expressed in the CENTRAL NERVOUS SYSTEM. Selectivity for calcium over sodium ranges from 0.5 to 10.
| Descriptor ID |
D050052
|
| MeSH Number(s) |
D12.776.157.530.400.901.500 D12.776.543.585.400.901.500
|
| Concept/Terms |
TRPC Cation Channels- TRPC Cation Channels
- Cation Channels, TRPC
- Channels, TRPC Cation
- Transient Receptor Potential Channels, Type C
- Transient Receptor Potential Cation Channel Subfamily C
|
Below are MeSH descriptors whose meaning is more general than "TRPC Cation Channels".
Below are MeSH descriptors whose meaning is more specific than "TRPC Cation Channels".
This graph shows the total number of publications written about "TRPC Cation Channels" by people in this website by year, and whether "TRPC Cation Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "TRPC Cation Channels" by people in Profiles.
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The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. Kidney Int. 2023 06; 103(6):1056-1062.
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Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy. Cells. 2023 01 10; 12(2).
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Ion channels and channelopathies in glomeruli. Physiol Rev. 2023 01 01; 103(1):787-854.
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TRPC6 Inactivation Reduces Albuminuria Induced by Protein Overload in Sprague Dawley Rats. Cells. 2022 06 21; 11(13).
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Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3527-3536.
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Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov; 27(11):3308-3319.
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Second Messenger-Operated Calcium Entry Through TRPC6. Adv Exp Med Biol. 2016; 898:201-49.
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Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2610-20.
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Pleiotropic signaling evoked by tumor necrosis factor in podocytes. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F98-108.
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Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes. Mol Pharmacol. 2014 Aug; 86(2):150-8.