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Stuart Dryer

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentBiology and Biochemistry
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-2697
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    Collapse Research 
    Collapse research activities and funding
    R01DK104708     (DRYER, STUART E)Dec 15, 2015 - Nov 30, 2024
    NIH
    Pathophysiology of FSGS
    Role: Principal Investigator
    R01DK082529     (DRYER, STUART E.)Sep 17, 2009 - Jun 30, 2012
    NIH
    Cellular Physiology of Podocytes
    Role: Principal Investigator
    R01DC004857     (DRYER, STUART E.)Mar 1, 2001 - Feb 28, 2006
    NIH
    Circadian Regulation of Olfaction
    Role: Principal Investigator
    R01EY011973     (DRYER, STUART E.)Aug 1, 1998 - Jul 31, 2007
    NIH
    CIRCADIAN REGULATION OF VERTEBRATE PHOTORECEPTORS
    Role: Principal Investigator
    R01NS032748     (DRYER, STUART E.)Mar 15, 1995 - Jan 31, 2007
    NIH
    DEVELOPMENT OF IONIC CHANNELS
    Role: Principal Investigator
    R29NS027013     (DRYER, STUART E.)Apr 1, 1989 - Mar 31, 1995
    NIH
    PROPERTIES OF SODIUM-ACTIVATED POTASSIUM CHANNELS
    Role: Principal Investigator
    F32NS007776     (DRYER, STUART E.)Nov 13, 1985
    NIH
    SYNAPTIC CHANNELS IN THE VERTEBRATE NEURVOUS SYSTEM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim EY, Rachubik P, Dryer SE. Dysregulation of Podocyte BK Channels and Nephrosis: Effects of Circulating Factors and Auxiliary ?4 Subunits. Cells. 2024 Dec 30; 14(1). PMID: 39791723; PMCID: PMC11719602.
      Citations:    Fields:    Translation:AnimalsCells
    2. Kim EY, Dryer SE. Role of Formyl Peptide Receptors and ?-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with aV?3-Integrin. Cells. 2024 01 17; 13(2). PMID: 38247863; PMCID: PMC10814688.
      Citations:    Fields:    Translation:AnimalsCells
    3. Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Suresh Kumar V, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, Staruschenko A, Reiser J. The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. Kidney Int. 2023 06; 103(6):1056-1062. PMID: 36750145; PMCID: PMC10200725.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Hagmann H, Khayyat NH, Matin M, Oezel C, Chen H, Schauss A, Schell C, Benzing T, Dryer S, Brinkkoetter PT. Capsazepine (CPZ) Inhibits TRPC6 Conductance and Is Protective in Adriamycin-Induced Nephropathy and Diabetic Glomerulopathy. Cells. 2023 01 10; 12(2). PMID: 36672207; PMCID: PMC9856956.
      Citations:    Fields:    Translation:Animals
    5. Dryer SE, Kim EY. The Effects of TRPC6 Knockout in Animal Models of Kidney Disease. Biomolecules. 2022 11 18; 12(11). PMID: 36421724; PMCID: PMC9687984.
      Citations: 5     Fields:    Translation:HumansAnimals
    6. Hagmann H, Khayyat NH, Oezel C, Papadakis A, Kuczkowski A, Benzing T, Gulbins E, Dryer S, Brinkkoetter PT. Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling. Cells. 2022 11 16; 11(22). PMID: 36429053; PMCID: PMC9688324.
      Citations: 1     Fields:    Translation:Animals
    7. Staruschenko A, Ma R, Palygin O, Dryer SE. Ion channels and channelopathies in glomeruli. Physiol Rev. 2023 01 01; 103(1):787-854. PMID: 36007181; PMCID: PMC9662803.
      Citations: 17     Fields:    Translation:Humans
    8. Kim EY, Dryer SE. TRPC6 Inactivation Reduces Albuminuria Induced by Protein Overload in Sprague Dawley Rats. Cells. 2022 06 21; 11(13). PMID: 35805070; PMCID: PMC9265922.
      Citations: 2     Fields:    Translation:Animals
    9. Mohammed Z, McHale C, Kubinak JL, Dryer S, Gomez G. miR-155 Is a Positive Regulator of FceRI-Induced Cyclooxygenase-2 Expression and Cytokine Production in Mast Cells. Front Allergy. 2022; 3:835776. PMID: 36211602; PMCID: PMC9543708.
      Citations: 3     
    10. Kim EY, Dryer SE. RAGE and aV?3-integrin are essential for suPAR signaling in podocytes. Biochim Biophys Acta Mol Basis Dis. 2021 10 01; 1867(10):166186. PMID: 34166766; PMCID: PMC8328937.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Kim EY, Dryer SE. Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats. Cells. 2021 04 09; 10(4). PMID: 33918778; PMCID: PMC8070418.
      Citations: 8     Fields:    Translation:Animals
    12. Hassanzadeh Khayyat N, Kim EY, Dryer SE. TRPC6 inactivation does not protect against diabetic kidney disease in streptozotocin (STZ)-treated Sprague-Dawley rats. FASEB Bioadv. 2019 Dec; 1(12):773-782. PMID: 32123821; PMCID: PMC6996301.
      Citations: 10     
    13. Dryer SE, Roshanravan H, Kim EY. TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1041-1066. PMID: 30953689.
      Citations: 45     Fields:    Translation:HumansCells
    14. Kim EY, Shotorbani PY, Dryer SE. TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions. Biochem Biophys Rep. 2019 Mar; 17:139-150. PMID: 30662960; PMCID: PMC6325086.
      Citations: 15     
    15. Kim EY, Hassanzadeh Khayyat N, Dryer SE. Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3527-3536. PMID: 30293571; PMCID: PMC6219472.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    16. Dryer SE, Kim EY. Permeation and Rectification in Canonical Transient Receptor Potential-6 (TRPC6) Channels. Front Physiol. 2018; 9:1055. PMID: 30123138; PMCID: PMC6085515.
      Citations: 9     
    17. Kim EY, Yazdizadeh Shotorbani P, Dryer SE. Trpc6 inactivation confers protection in a model of severe nephrosis in rats. J Mol Med (Berl). 2018 07; 96(7):631-644. PMID: 29785489; PMCID: PMC6015123.
      Citations: 36     Fields:    Translation:Animals
    18. Kim EY, Roshanravan H, Dryer SE. Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. Biochim Biophys Acta Mol Basis Dis. 2017 09; 1863(9):2342-2354. PMID: 28629718; PMCID: PMC5557291.
      Citations: 31     Fields:    Translation:HumansCells
    19. Roshanravan H, Kim EY, Dryer SE. 20-Hydroxyeicosatetraenoic Acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes. Front Physiol. 2016; 7:351. PMID: 27630573; PMCID: PMC5005377.
      Citations: 14     
    20. Roshanravan H, Kim EY, Dryer SE. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801. Diabetes. 2016 10; 65(10):3139-50. PMID: 27388219; PMCID: PMC5033270.
      Citations: 16     Fields:    Translation:AnimalsCells
    21. Yu H, Kistler A, Faridi MH, Meyer JO, Tryniszewska B, Mehta D, Yue L, Dryer S, Reiser J. Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov; 27(11):3308-3319. PMID: 27020855; PMCID: PMC5084886.
      Citations: 27     Fields:    Translation:AnimalsCells
    22. Bouron A, Chauvet S, Dryer S, Rosado JA. Second Messenger-Operated Calcium Entry Through TRPC6. Adv Exp Med Biol. 2016; 898:201-49. PMID: 27161231.
      Citations: 16     Fields:    
    23. Kim EY, Roshanravan H, Dryer SE. Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2610-20. PMID: 26193076.
      Citations: 19     Fields:    Translation:AnimalsCells
    24. Abkhezr M, Kim EY, Roshanravan H, Nikolos F, Thomas C, Hagmann H, Benzing T, Dryer SE. Pleiotropic signaling evoked by tumor necrosis factor in podocytes. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F98-108. PMID: 26017975.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Dryer SE. Glutamate receptors in the kidney. Nephrol Dial Transplant. 2015 Oct; 30(10):1630-8. PMID: 25829324.
      Citations: 21     Fields:    Translation:HumansAnimals
    26. Lin J, Shi Y, Peng H, Shen X, Thomas S, Wang Y, Truong LD, Dryer SE, Hu Z, Xu J. Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy. J Pathol. 2015 May; 236(1):30-40. PMID: 25641678; PMCID: PMC4398628.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    27. Abkhezr M, Dryer SE. STAT3 regulates steady-state expression of synaptopodin in cultured mouse podocytes. Mol Pharmacol. 2015 Feb; 87(2):231-9. PMID: 25425624.
      Citations: 5     Fields:    
    28. Abkhezr M, Dryer SE. Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes. Mol Pharmacol. 2014 Aug; 86(2):150-8. PMID: 24850910.
      Citations: 7     Fields:    
    29. Anderson M, Roshanravan H, Khine J, Dryer SE. Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. J Cell Physiol. 2014 Apr; 229(4):434-42. PMID: 24037962.
      Citations: 49     Fields:    Translation:AnimalsCells
    30. Rinschen MM, Wu X, K?nig T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T. Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol. 2014 Jul; 25(7):1509-22. PMID: 24511133; PMCID: PMC4073431.
      Citations: 24     Fields:    Translation:AnimalsCells
    31. Kim EY, Anderson M, Wilson C, Hagmann H, Benzing T, Dryer SE. NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex. Am J Physiol Cell Physiol. 2013 Nov 01; 305(9):C960-71. PMID: 23948707.
      Citations: 41     Fields:    Translation:AnimalsCells
    32. Anderson M, Kim EY, Hagmann H, Benzing T, Dryer SE. Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. 2013 Aug 01; 305(3):C276-89. PMID: 23657570.
      Citations: 62     Fields:    
    33. Kim EY, Anderson M, Dryer SE. Sustained activation of N-methyl-D-aspartate receptors in podoctyes leads to oxidative stress, mobilization of transient receptor potential canonical 6 channels, nuclear factor of activated T cells activation, and apoptotic cell death. Mol Pharmacol. 2012 Oct; 82(4):728-37. PMID: 22828802; PMCID: PMC3463221.
      Citations: 25     Fields:    
    34. Kim EY, Dryer SE. Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes. J Cell Physiol. 2011 Sep; 226(9):2307-15. PMID: 21660954; PMCID: PMC3089709.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    35. Alvarez-Baron CP, Jonsson P, Thomas C, Dryer SE, Williams C. The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells. Mol Endocrinol. 2011 Aug; 25(8):1326-36. PMID: 21680658; PMCID: PMC3146246.
      Citations: 31     Fields:    Translation:HumansCells
    36. Anderson M, Suh JM, Kim EY, Dryer SE. Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C22-32. PMID: 20739624; PMCID: PMC3023196.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    37. Kim EY, Suh JM, Chiu YH, Dryer SE. Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments. Am J Physiol Renal Physiol. 2010 Sep; 299(3):F594-604. PMID: 20630939; PMCID: PMC2944294.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    38. Chiu YH, Alvarez-Baron C, Kim EY, Dryer SE. Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of an Slo1 calcium-activated potassium channel splice variant. Mol Pharmacol. 2010 Apr; 77(4):497-507. PMID: 20051533; PMCID: PMC2845944.
      Citations: 22     Fields:    
    39. Jha S, Dryer SE. The beta1 subunit of Na+/K+-ATPase interacts with BKCa channels and affects their steady-state expression on the cell surface. FEBS Lett. 2009 Oct 06; 583(19):3109-14. PMID: 19729011; PMCID: PMC2757478.
      Citations: 8     Fields:    Translation:Animals
    40. Kim EY, Alvarez-Baron CP, Dryer SE. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes. Mol Pharmacol. 2009 Mar; 75(3):466-77. PMID: 19052171; PMCID: PMC2645922.
      Citations: 48     Fields:    
    41. Kim EY, Choi KJ, Dryer SE. Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F235-46. PMID: 18480178; PMCID: PMC2494500.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    42. Zou S, Jha S, Kim EY, Dryer SE. A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membrane. Mol Pharmacol. 2008 Feb; 73(2):359-68. PMID: 17989352.
      Citations: 17     Fields:    
    43. Zou S, Jha S, Kim EY, Dryer SE. The beta 1 subunit of L-type voltage-gated Ca2+ channels independently binds to and inhibits the gating of large-conductance Ca2+-activated K+ channels. Mol Pharmacol. 2008 Feb; 73(2):369-78. PMID: 17989350.
      Citations: 12     Fields:    
    44. Chen SK, Ko GY, Dryer SE. Somatostatin peptides produce multiple effects on gating properties of native cone photoreceptor cGMP-gated channels that depend on circadian phase and previous illumination. J Neurosci. 2007 Nov 07; 27(45):12168-75. PMID: 17989283; PMCID: PMC6673241.
      Citations: 7     Fields:    Translation:AnimalsCells
    45. Kim EY, Ridgway LD, Dryer SE. Interactions with filamin A stimulate surface expression of large-conductance Ca2+-activated K+ channels in the absence of direct actin binding. Mol Pharmacol. 2007 Sep; 72(3):622-30. PMID: 17586600.
      Citations: 27     Fields:    
    46. Kim EY, Zou S, Ridgway LD, Dryer SE. Beta1-subunits increase surface expression of a large-conductance Ca2+-activated K+ channel isoform. J Neurophysiol. 2007 May; 97(5):3508-16. PMID: 17329633.
      Citations: 34     Fields:    Translation:HumansCells
    47. Bryan RM, You J, Phillips SC, Andresen JJ, Lloyd EE, Rogers PA, Dryer SE, Marrelli SP. Evidence for two-pore domain potassium channels in rat cerebral arteries. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H770-80. PMID: 16565299.
      Citations: 28     Fields:    Translation:Animals
    48. Chae KS, Dryer SE. The p38 mitogen-activated protein kinase pathway negatively regulates Ca2+-activated K+ channel trafficking in developing parasympathetic neurons. J Neurochem. 2005 Jul; 94(2):367-79. PMID: 15998288.
      Citations: 13     Fields:    Translation:AnimalsCells
    49. Chae KS, Oh KS, Dryer SE. Growth factors mobilize multiple pools of KCa channels in developing parasympathetic neurons: role of ADP-ribosylation factors and related proteins. J Neurophysiol. 2005 Aug; 94(2):1597-605. PMID: 15843480.
      Citations: 7     Fields:    Translation:AnimalsCells
    50. Krishnan P, Dryer SE, Hardin PE. Measuring circadian rhythms in olfaction using electroantennograms. Methods Enzymol. 2005; 393:495-508. PMID: 15817308.
      Citations: 7     Fields:    Translation:AnimalsCells
    51. Chae KS, Martin-Caraballo M, Anderson M, Dryer SE. Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. J Neurophysiol. 2005 Mar; 93(3):1174-82. PMID: 15509648.
      Citations: 21     Fields:    Translation:AnimalsCells
    52. Ko GY, Ko M, Dryer SE. Circadian and cAMP-dependent modulation of retinal cone cGMP-gated channels does not require protein synthesis or calcium influx through L-type channels. Brain Res. 2004 Sep 24; 1021(2):277-80. PMID: 15342277.
      Citations: 9     Fields:    Translation:AnimalsCells
    53. Casavant RH, Colbert CM, Dryer SE. A-current expression is regulated by activity but not by target tissues in developing lumbar motoneurons of the chick embryo. J Neurophysiol. 2004 Nov; 92(5):2644-51. PMID: 15163671.
      Citations: 8     Fields:    Translation:AnimalsCells
    54. Tanoue S, Krishnan P, Krishnan B, Dryer SE, Hardin PE. Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila. Curr Biol. 2004 Apr 20; 14(8):638-49. PMID: 15084278.
      Citations: 109     Fields:    Translation:AnimalsCells
    55. Ko GY, Ko ML, Dryer SE. Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras. J Neurosci. 2004 Feb 11; 24(6):1296-304. PMID: 14960600; PMCID: PMC2667374.
      Citations: 31     Fields:    Translation:AnimalsCells
    56. Lhuillier L, Dryer SE. Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons. Brain Res. 2003 Aug 22; 982(1):119-24. PMID: 12915246.
      Citations: 2     Fields:    Translation:AnimalsCells
    57. Ko GY, Ko ML, Dryer SE. Circadian phase-dependent modulation of cGMP-gated channels of cone photoreceptors by dopamine and D2 agonist. J Neurosci. 2003 Apr 15; 23(8):3145-53. PMID: 12716922; PMCID: PMC2667621.
      Citations: 25     Fields:    Translation:AnimalsCells
    58. Dryer SE. Molecular identification of the Na+-activated K+ channel. Neuron. 2003 Mar 06; 37(5):727-8. PMID: 12628162.
      Citations: 10     Fields:    Translation:Animals
    59. Hardin PE, Krishnan B, Houl JH, Zheng H, Ng FS, Dryer SE, Glossop NR. Central and peripheral circadian oscillators in Drosophila. Novartis Found Symp. 2003; 253:140-50; discussion 150-60. PMID: 14712919.
      Citations: 6     Fields:    Translation:AnimalsCells
    60. Dryer SE, Lhuillier L, Cameron JS, Martin-Caraballo M. Expression of K(Ca) channels in identified populations of developing vertebrate neurons: role of neurotrophic factors and activity. J Physiol Paris. 2003 Jan; 97(1):49-58. PMID: 14706690.
      Citations: 11     Fields:    Translation:AnimalsCells
    61. Martin-Caraballo M, Dryer SE. Glial cell line-derived neurotrophic factor and target-dependent regulation of large-conductance KCa channels in developing chick lumbar motoneurons. J Neurosci. 2002 Dec 01; 22(23):10201-8. PMID: 12451121; PMCID: PMC6758763.
      Citations: 10     Fields:    Translation:AnimalsCells
    62. Lhuillier L, Dryer SE. Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion. J Neurophysiol. 2002 Aug; 88(2):954-64. PMID: 12163544.
      Citations: 22     Fields:    Translation:AnimalsCells
    63. Martin-Caraballo M, Dryer SE. Activity- and target-dependent regulation of large-conductance Ca2+-activated K+ channels in developing chick lumbar motoneurons. J Neurosci. 2002 Jan 01; 22(1):73-81. PMID: 11756490; PMCID: PMC6757614.
      Citations: 9     Fields:    Translation:AnimalsCells
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