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Tahir Hussain

TitleProfessor
InstitutionUniversity of Houston
DepartmentPharmacological and Pharmaceutical Sciences
Address4800 Calhoun Rd
Houston TX 77004
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    R01DK117495     (HUSSAIN, TAHIR)May 1, 2018 - Mar 31, 2022
    NIH
    Protective Arm of the Renin Angiotensin System in Obese Kidney
    Role: Principal Investigator
    R01DK061578     (HUSSAIN, TAHIR)Apr 1, 2002 - Apr 30, 2021
    NIH
    Renal angiotensin II receptor function in obesity
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McPherson JK, Hurdle JG, Baker ML, Hussain T, Kumar A, Garey KW. The microbiome-restorative potential of ibezapolstat for the treatment of Clostridioides difficile infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae. Antimicrob Agents Chemother. 2025 Feb 21; e0167924. PMID: 39982073.
      Citations:    Fields:    
    2. Abdulkareem NM, Bhat R, Castillo M, Jung SY, Vasaikar S, Nanda S, Ruiz A, Shea M, Cao W, Veeraraghavan J, Kim HY, Bawa-Khalfe T, Hussain T, Liu X, Gunaratne P, Schiff R, Trivedi MV. Interactions between ADGRF1 (GPR110) and extracellular matrix proteins govern its effects on tumorigenesis in HER2-positive breast cancer. Br J Pharmacol. 2025 Feb 18. PMID: 39965212.
      Citations:    Fields:    
    3. Faisal T, Hussain T. GPCR dimerization: Drug discovery aspects and targets in renin-angiotensin systems. FASEB Bioadv. 2025 Mar; 7(3):e1486. PMID: 40060944; PMCID: PMC11886600.
      Citations:    
    4. Kulkarni K, Hussain T. Megalin: A Sidekick or Nemesis of the Kidney? J Am Soc Nephrol. 2025 Feb 01; 36(2):293-300. PMID: 39607686; PMCID: PMC11801750.
      Citations:    Fields:    
    5. Patel SN, Kulkarni K, Faisal T, Hussain T. Angiotensin-II type 2 receptor-mediated renoprotection is independent of receptor Mas in obese Zucker rats fed high-sodium diet. Front Pharmacol. 2024; 15:1409313. PMID: 39135807; PMCID: PMC11317439.
      Citations:    
    6. Fatima N, Ali R, Faisal T, Kulkarni K, Patel S, Hussain T. Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury. Am J Physiol Renal Physiol. 2023 11 01; 325(5):F552-F563. PMID: 37615049; PMCID: PMC10878726.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Sharma B, Rehman MT, AlAjmi MF, Shahwan M, Hussain T, Jaiswal V, Khan MA. Computational investigation of the impact of potential AT2R polymorphism on small molecule binding. J Biomol Struct Dyn. 2024 Mar; 42(5):2231-2241. PMID: 37116071.
      Citations: 1     Fields:    
    8. Kulkarni K, Patel S, Ali R, Hussain T. Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats. Sci Rep. 2023 03 15; 13(1):4277. PMID: 36922642; PMCID: PMC10017765.
      Citations: 2     Fields:    Translation:Animals
    9. Patel S, Kulkarni K, Hussain T. Protecting glomerulus: role of angiotensin-II type 2 receptor. Clin Sci (Lond). 2022 10 28; 136(20):1467-1470. PMID: 36287192.
      Citations: 1     Fields:    Translation:HumansCells
    10. Steckelings UM, Widdop RE, Sturrock ED, Lubbe L, Hussain T, Kaschina E, Unger T, Hallberg A, Carey RM, Sumners C. The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target. Pharmacol Rev. 2022 10; 74(4):1051-1135. PMID: 36180112; PMCID: PMC9553111.
      Citations: 22     Fields:    Translation:HumansCells
    11. Gray EA, Patel SN, Doris PA, Hussain T. Combining Neprilysin Inhibitor With AT2R Agonist Is Superior to Combination With AT1R Blocker in Providing Reno-Protection in Obese Rats. Front Pharmacol. 2021; 12:778953. PMID: 35197849; PMCID: PMC8859315.
      Citations: 1     
    12. Sharma B, Hussain T, Khan MA, Jaiswal V. Exploring AT2R and its Polymorphism in Different Diseases: An Approach to Develop AT2R as a Drug Target beyond Hypertension. Curr Drug Targets. 2022; 23(1):99-113. PMID: 34365920.
      Citations: 4     Fields:    Translation:Humans
    13. Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021; 12:600163. PMID: 33935698; PMCID: PMC8082177.
      Citations: 10     
    14. Fatima N, Patel SN, Hussain T. Angiotensin II Type 2 Receptor: A Target for Protection Against Hypertension, Metabolic Dysfunction, and Organ Remodeling. Hypertension. 2021 06; 77(6):1845-1856. PMID: 33840201; PMCID: PMC8115429.
      Citations: 28     Fields:    Translation:HumansAnimals
    15. Bhatt LK, Selokar I, Raut D, Hussain T. Novel Targets for Hypertension Drug Discovery. Curr Hypertens Rep. 2021 Mar 30; 23(4):19. PMID: 33783647.
      Citations: 2     Fields:    Translation:Humans
    16. Ali R, Patel S, Hussain T. Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia. Am J Physiol Renal Physiol. 2021 05 01; 320(5):F814-F825. PMID: 33719572; PMCID: PMC8424555.
      Citations: 15     Fields:    Translation:AnimalsCells
    17. Patel S, Hussain T. Synergism between Angiotensin receptors ligands: Role of Angiotensin-(1-7) in modulating AT2 R agonist response on nitric oxide in kidney cells. Pharmacol Res Perspect. 2020 12; 8(6):e00667. PMID: 33197136; PMCID: PMC7668194.
      Citations: 3     Fields:    Translation:HumansCells
    18. Patel SN, Fatima N, Ali R, Hussain T. Emerging Role of Angiotensin AT2 Receptor in Anti-Inflammation: An Update. Curr Pharm Des. 2020; 26(4):492-500. PMID: 31939729; PMCID: PMC7457547.
      Citations: 13     Fields:    Translation:HumansCells
    19. Zhang Y, Wang YT, Koka S, Zhang Y, Hussain T, Li X. Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells. Front Biosci (Landmark Ed). 2020 Jan 01; 25(2):283-298. PMID: 31585890; PMCID: PMC6812495.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    20. Nag S, Patel S, Mani S, Hussain T. Role of angiotensin type 2 receptor in improving lipid metabolism and preventing adiposity. Mol Cell Biochem. 2019 Nov; 461(1-2):195-204. PMID: 31414336; PMCID: PMC6790297.
      Citations: 9     Fields:    Translation:AnimalsCells
    21. Patel S, Dhande I, Gray EA, Ali Q, Hussain T. Prevention of lipopolysaccharide-induced CD11b+ immune cell infiltration in the kidney: role of AT2 receptors. Biosci Rep. 2019 05 31; 39(5). PMID: 31072913; PMCID: PMC6533357.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    22. Patel S, Hussain T. Correction to: Dimerization of AT2 and Mas Receptors in Control of Blood Pressure. Curr Hypertens Rep. 2018 05 12; 20(5):47. PMID: 29754183.
      Citations: 1     Fields:    
    23. Patel S, Hussain T. Dimerization of AT2 and Mas Receptors in Control of Blood Pressure. Curr Hypertens Rep. 2018 05 01; 20(5):41. PMID: 29717388; PMCID: PMC7479989.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    24. Patel SN, Narayan P, Goldberg ID, Naaz F, Hussain T, Ali Q. Kidney Appreciates Stable Blood Pressure. Am J Hypertens. 2018 04 13; 31(5):532-533. PMID: 29272328; PMCID: PMC5905659.
      Citations:    Fields:    Translation:Humans
    25. Patel S, Hussain T. Role of AT2R (Angiotensin Type 2 Receptor) in Maintaining Sodium-Potassium Balance. Hypertension. 2018 04; 71(4):563-565. PMID: 29483226; PMCID: PMC5843541.
      Citations: 2     Fields:    
    26. Boini KM, Hussain T, Li PL, Koka S. Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction. Cell Physiol Biochem. 2017; 44(1):152-162. PMID: 29130962; PMCID: PMC5828122.
      Citations: 124     Fields:    Translation:AnimalsCells
    27. Patel SN, Ali Q, Samuel P, Steckelings UM, Hussain T. Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney. Hypertension. 2017 10; 70(4):831-838. PMID: 28827476; PMCID: PMC5599348.
      Citations: 26     Fields:    Translation:Animals
    28. Ali Q, Dhande I, Samuel P, Hussain T. Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury. J Renin Angiotensin Aldosterone Syst. 2016 Jul; 17(3). PMID: 27496559; PMCID: PMC5843939.
      Citations: 14     Fields:    Translation:Animals
    29. Patel SN, Ali Q, Hussain T. Angiotensin II Type 2-Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt-Fed Obese Zucker Rats. Hypertension. 2016 May; 67(5):906-15. PMID: 27021008; PMCID: PMC4833537.
      Citations: 21     Fields:    Translation:Animals
    30. Ali Q, Patel S, Hussain T. Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1379-85. PMID: 25855512; PMCID: PMC4469886.
      Citations: 30     Fields:    Translation:Animals
    31. Nag S, Khan MA, Samuel P, Ali Q, Hussain T. Chronic angiotensin AT2R activation prevents high-fat diet-induced adiposity and obesity in female mice independent of estrogen. Metabolism. 2015 Jul; 64(7):814-25. PMID: 25869303; PMCID: PMC4437825.
      Citations: 15     Fields:    Translation:Animals
    32. Dhande I, Ma W, Hussain T. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertens Res. 2015 Jan; 38(1):21-9. PMID: 25209104; PMCID: PMC4898267.
      Citations: 41     Fields:    Translation:HumansCells
    33. Ali Q, Wu Y, Nag S, Hussain T. Estimation of angiotensin peptides in biological samples by LC/MS method. Anal Methods. 2014 Jan 21; 6(1):215-222. PMID: 24489613; PMCID: PMC3904384.
      Citations: 12     Fields:    
    34. Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int. 2013 Nov; 84(5):931-9. PMID: 23823602; PMCID: PMC4091804.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    35. Dhande I, Ali Q, Hussain T. Proximal tubule angiotensin AT2 receptors mediate an anti-inflammatory response via interleukin-10: role in renoprotection in obese rats. Hypertension. 2013 Jun; 61(6):1218-26. PMID: 23547236; PMCID: PMC3709839.
      Citations: 47     Fields:    Translation:HumansAnimals
    36. Samuel P, Khan MA, Nag S, Inagami T, Hussain T. Angiotensin AT(2) receptor contributes towards gender bias in weight gain. PLoS One. 2013; 8(1):e48425. PMID: 23341867; PMCID: PMC3546084.
      Citations: 22     Fields:    Translation:HumansAnimals
    37. Ali Q, Hussain T. AT2 receptor: Its role in obesity associated hypertension. Int J Clin Pharmacol Toxicol. 2012 Oct; 1(1):15-19. PMID: 27588222; PMCID: PMC5004927.
      Citations: 1     
    38. Asghar M, Tayebati SK, Lokhandwala MF, Hussain T. Potential dopamine-1 receptor stimulation in hypertension management. Curr Hypertens Rep. 2011 Aug; 13(4):294-302. PMID: 21633929.
      Citations: 22     Fields:    Translation:Humans
    39. Sabuhi R, Ali Q, Asghar M, Al-Zamily NR, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol. 2011 Mar; 300(3):F700-6. PMID: 21209001; PMCID: PMC3064141.
      Citations: 44     Fields:    Translation:Animals
    40. Ali Q, Sabuhi R, Hussain T. High glucose up-regulates angiotensin II subtype 2 receptors via interferon regulatory factor-1 in proximal tubule epithelial cells. Mol Cell Biochem. 2010 Nov; 344(1-2):65-71. PMID: 20596758; PMCID: PMC3912838.
      Citations: 13     Fields:    Translation:AnimalsCells
    41. Siddiqui AH, Ali Q, Hussain T. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension. 2009 Feb; 53(2):256-61. PMID: 19114640; PMCID: PMC2746398.
      Citations: 23     Fields:    Translation:Animals
    42. Siddiqui AH, Hussain T. Impaired angiotensin II AT(1) receptor function and enhanced Na, K-ATPase affinity for sodium in proximal tubule of streptozotocin-treated diabetic rats. Clin Exp Hypertens. 2007 Oct; 29(7):435-44. PMID: 17994353.
      Citations: 3     Fields:    Translation:AnimalsCells
    43. Shahid G, Hussain T. GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. J Biol Chem. 2007 Jul 13; 282(28):20612-20. PMID: 17517892.
      Citations: 17     Fields:    Translation:AnimalsCells
    44. Siddiqui AH, Hussain T. Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1722-7. PMID: 17142345.
      Citations: 10     Fields:    Translation:AnimalsCells
    45. Hakam AC, Hussain T. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension. 2006 Jun; 47(6):1117-24. PMID: 16618840.
      Citations: 28     Fields:    Translation:AnimalsCells
    46. Shah S, Hussain T. Enhanced angiotensin II-induced activation of Na+, K+-ATPase in the proximal tubules of obese Zucker rats. Clin Exp Hypertens. 2006 Jan; 28(1):29-40. PMID: 16443562.
      Citations: 25     Fields:    Translation:AnimalsCells
    47. Hakam AC, Siddiqui AH, Hussain T. Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabetic rats. Am J Physiol Renal Physiol. 2006 Feb; 290(2):F503-8. PMID: 16204414.
      Citations: 28     Fields:    Translation:Animals
    48. Banday AA, Siddiqui AH, Menezes MM, Hussain T. Insulin treatment enhances AT1 receptor function in OK cells. Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1213-9. PMID: 15713908.
      Citations: 9     Fields:    Translation:AnimalsCells
    49. Hakam AC, Hussain T. Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension. 2005 Feb; 45(2):270-5. PMID: 15596573.
      Citations: 38     Fields:    Translation:AnimalsCells
    50. Narkar V, Kunduzova O, Hussain T, Cambon C, Parini A, Lokhandwala M. Dopamine D2-like receptor agonist bromocriptine protects against ischemia/reperfusion injury in rat kidney. Kidney Int. 2004 Aug; 66(2):633-40. PMID: 15253716.
      Citations: 10     Fields:    Translation:AnimalsCells
    51. Trivedi M, Narkar VA, Hussain T, Lokhandwala MF. Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F921-31. PMID: 15265765.
      Citations: 12     Fields:    Translation:AnimalsCells
    52. Banday AA, Hussain T, Lokhandwala MF. Renal dopamine D(1) receptor dysfunction is acquired and not inherited in obese Zucker rats. Am J Physiol Renal Physiol. 2004 Jul; 287(1):F109-16. PMID: 15068975.
      Citations: 9     Fields:    Translation:Animals
    53. Hussain T. Renal angiotensin II receptors, hyperinsulinemia, and obesity. Clin Exp Hypertens. 2003 Oct; 25(7):395-403. PMID: 14596364.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    54. Asghar M, Hussain T, Lokhandwala MF. Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1100-7. PMID: 12904329.
      Citations: 6     Fields:    Translation:Animals
    55. Banday AA, Asghar M, Hussain T, Lokhandwala MF. Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin. Hypertension. 2003 Jun; 41(6):1353-8. PMID: 12707290.
      Citations: 16     Fields:    Translation:AnimalsCells
    56. Hussain T, Lokhandwala MF. Renal dopamine receptors and hypertension. Exp Biol Med (Maywood). 2003 Feb; 228(2):134-42. PMID: 12563019.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    57. Becker M, Umrani D, Lokhandwala MF, Hussain T. Increased renal angiotensin II AT1 receptor function in obese Zucker rat. Clin Exp Hypertens. 2003 Jan; 25(1):35-47. PMID: 12597523.
      Citations: 14     Fields:    Translation:Animals
    58. Umrani DN, Banday AA, Hussain T, Lokhandwala MF. Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension. 2002 Dec; 40(6):880-5. PMID: 12468573.
      Citations: 13     Fields:    Translation:AnimalsCells
    59. Asghar M, Hussain T, Lokhandwala MF. Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F350-5. PMID: 12110520.
      Citations: 9     Fields:    Translation:AnimalsCells
    60. Narkar VA, Hussain T, Lokhandwala MF. Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1290-5. PMID: 12388408.
      Citations: 4     Fields:    Translation:AnimalsCells
    61. Narkar V, Hussain T, Lokhandwala M. Role of tyrosine kinase and p44/42 MAPK in D(2)-like receptor-mediated stimulation of Na(+), K(+)-ATPase in kidney. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F697-702. PMID: 11880331.
      Citations: 10     Fields:    Translation:AnimalsCells
    62. Narkar VA, Hussain T, Pedemonte C, Lokhandwala MF. Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells. J Am Soc Nephrol. 2001 Sep; 12(9):1844-1852. PMID: 11518777.
      Citations: 8     Fields:    Translation:AnimalsCells
    63. Asghar M, Kansra V, Hussain T, Lokhandwala MF. Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J Am Soc Nephrol. 2001 Feb; 12(2):226-232. PMID: 11158212.
      Citations: 7     Fields:    Translation:AnimalsCells
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