"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 2 | 3 |
| 2003 | 1 | 3 | 4 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 3 | 4 |
| 2007 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 2 | 3 |
| 2011 | 1 | 4 | 5 |
| 2012 | 1 | 1 | 2 |
| 2013 | 5 | 3 | 8 |
| 2014 | 3 | 6 | 9 |
| 2015 | 5 | 4 | 9 |
| 2016 | 1 | 10 | 11 |
| 2017 | 6 | 6 | 12 |
| 2018 | 3 | 7 | 10 |
| 2019 | 2 | 10 | 12 |
| 2020 | 4 | 13 | 17 |
| 2021 | 2 | 16 | 18 |
| 2022 | 0 | 3 | 3 |
| 2023 | 1 | 5 | 6 |
| 2024 | 6 | 13 | 19 |
| 2025 | 2 | 5 | 7 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Tunneling nanotube-like structures regulate distant cellular interactions during heart formation. Science. 2025 Mar 14; 387(6739):eadd3417.
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The complex roles of IL-36 and IL-38 in cancer: friends or foes? Oncogene. 2025 Apr; 44(13):851-861.
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Acid Sphingomyelinase Regulates AdipoRon-Induced Differentiation of Arterial Smooth Muscle Cells via TFEB Activation. Int J Mol Sci. 2025 Feb 27; 26(5).
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Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair. JCI Insight. 2025 Jan 28; 10(5).
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Integrated transcriptome and metabolome analysis of liver reveals unsynchronized growth mechanisms in blunt-snout bream (Megalobrama amblycephala). BMC Genomics. 2025 Jan 13; 26(1):30.
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Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. Sci Adv. 2025 Jan 10; 11(2):eadq8114.
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Cirsii Herba glycoprotein promotes macrophage M1 polarization through MAPK and NF-?B signaling pathways via interaction with TLR4. Int J Biol Macromol. 2025 Mar; 296:139687.
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SALL4 mediates SHP2 inhibition in myocardial fibroblasts through the DOT1L/H3K79me2 signaling pathway to promote the progression of myocardial infarction. Sci Rep. 2024 Dec 28; 14(1):30938.
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LincR-PPP2R5C regulates the PP2A signaling pathway in the macrophage-myofibroblast transition in a mouse model of epidural fibrosis. Mol Immunol. 2025 Jan; 177:85-95.
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The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1a in Vascular Calcification. Biomolecules. 2024 Dec 12; 14(12).