"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
| Descriptor ID |
D000478
|
| MeSH Number(s) |
G02.111.035 G02.607.094 G03.059
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Alkylation".
Below are MeSH descriptors whose meaning is more specific than "Alkylation".
This graph shows the total number of publications written about "Alkylation" by people in this website by year, and whether "Alkylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alkylation" by people in Profiles.
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Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020 04 17; 15(4):1036-1049.
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1-Aminopyridinium Ylides as Monodentate Directing Groups for sp3 C-H Bond Functionalization. J Am Chem Soc. 2019 09 18; 141(37):14728-14735.
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Cobalt-Catalyzed Coupling of Benzoic Acid C-H Bonds with Alkynes, Styrenes, and 1,3-Dienes. Angew Chem Int Ed Engl. 2018 02 05; 57(6):1688-1691.
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Cobalt-catalyzed, aminoquinoline-directed C(sp?)-H bond alkenylation by alkynes. Angew Chem Int Ed Engl. 2014 Sep 15; 53(38):10209-12.
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Scope and limitations of auxiliary-assisted, palladium-catalyzed arylation and alkylation of sp2 and sp3 C-H bonds. J Org Chem. 2013 Oct 04; 78(19):9689-714.
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Transition-metal-free alkynylation of aryl chlorides. Org Lett. 2011 Aug 19; 13(16):4172-5.
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Biofunctionalization on alkylated silicon substrate surfaces via "click" chemistry. J Am Chem Soc. 2010 Nov 24; 132(46):16432-41.
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Iron-catalyzed heterocycle and arene deprotonative alkylation. Org Lett. 2010 Oct 01; 12(19):4277-9.
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Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bonds. J Am Chem Soc. 2010 Mar 24; 132(11):3965-72.