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Alexander V. Statsyuk

TitleAssistant Professor
InstitutionUniversity of Houston
DepartmentPharmacological and Pharmaceutical Sciences
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Research 
    Collapse research activities and funding
    R21GM147836     (STATSYUK, ALEXANDER V)Sep 1, 2022 - Aug 31, 2024
    NIH
    Chemical platform to produce covalent biologics
    Role: Principal Investigator
    R01GM115632     (STATSYUK, ALEXANDER V)Jul 1, 2015 - Jun 30, 2021
    NIH
    Pharmacological Inhibitors of Nedd4 ubiquitin ligase as anticancer therapeutics
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chowdhury SR, Chuong P, Mgbemena VE, Statsyuk A. Development of a PROTAC Targeting Chk1. bioRxiv. 2024 Jan 01. PMID: 38260247; PMCID: PMC10802242.
      Citations:    
    2. Statsyuk AV. Inhibiting protein synthesis to treat malaria. Science. 2022 06 03; 376(6597):1049-1050. PMID: 35653471.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020 04 17; 15(4):1036-1049. PMID: 32149490; PMCID: PMC7271629.
      Citations: 17     Fields:    Translation:HumansCells
    4. Parker BW, Goncz EJ, Krist DT, Statsyuk AV, Nesvizhskii AI, Weiss EL. Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21001-21011. PMID: 31578253; PMCID: PMC6800362.
      Citations: 9     Fields:    Translation:HumansCells
    5. Kathman SG, Statsyuk AV. Methodology for Identification of Cysteine-Reactive Covalent Inhibitors. Methods Mol Biol. 2019; 1967:245-262. PMID: 31069775.
      Citations: 1     Fields:    Translation:HumansCells
    6. Chowdhury SR, Kennedy S, Zhu K, Mishra R, Chuong P, Nguyen AU, Kathman SG, Statsyuk AV. Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments. Bioorg Med Chem Lett. 2019 01 01; 29(1):36-39. PMID: 30455147; PMCID: PMC6319256.
      Citations: 10     Fields:    Translation:HumansCells
    7. Ramirez YA, Adler TB, Altmann E, Klemm T, Tiesmeyer C, Sauer F, Kathman SG, Statsyuk AV, Sotriffer C, Kisker C. Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem. 2018 10 08; 13(19):2014-2023. PMID: 30028574; PMCID: PMC6177307.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. Foote PK, Statsyuk AV. Monitoring PARKIN RBR Ubiquitin Ligase Activation States with UbFluor. Curr Protoc Chem Biol. 2018 09; 10(3):e45. PMID: 30063295; PMCID: PMC6125222.
      Citations: 1     Fields:    Translation:HumansCells
    9. Statsyuk AV. Let K-Ras activate its own inhibitor. Nat Struct Mol Biol. 2018 06; 25(6):435-437. PMID: 29760530.
      Citations: 2     Fields:    Translation:HumansCells
    10. Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018 01 23; 8(1):1405. PMID: 29362455; PMCID: PMC5780509.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    11. Foote PK, Krist DT, Statsyuk AV. High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor. Curr Protoc Chem Biol. 2017 Sep 14; 9(3):174-195. PMID: 28910856; PMCID: PMC5650195.
      Citations: 5     Fields:    Translation:Humans
    12. Park S, Foote PK, Krist DT, Rice SE, Statsyuk AV. UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN. J Biol Chem. 2017 10 06; 292(40):16539-16553. PMID: 28710279; PMCID: PMC5633118.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Misra M, Kuhn M, L?bel M, An H, Statsyuk AV, Sotriffer C, Schindelin H. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 07 05; 25(7):1120-1129.e3. PMID: 28578874.
      Citations: 17     Fields:    Translation:HumansCells
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