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Gregory Cuny

TitleProfessor
InstitutionUniversity of Houston
DepartmentPharmacological and Pharmaceutical Sciences
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Research 
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    R21AI164003     (CUNY, GREGORY D ;DEGTEREV, ALEXEI)May 20, 2021 - Apr 30, 2024
    NIH
    Degrader probes for necroptosis pathway
    Role: Principal Investigator
    R01AI144400     (BALACHANDRAN, SIDDHARTH)Sep 18, 2019 - Aug 31, 2024
    NIH
    Targeting RIPK3 in Flu-Associated Lung Injury
    Role: Co-Principal Investigator
    R21NS111395     (DEGTEREV, ALEXEI)May 1, 2019 - Apr 30, 2021
    NIH
    Targeting RIPK1 and RIPK2 kinases in mouse Experimental Autoimmune Encephalomyelitis
    Role: Co-Principal Investigator
    R56AG058642     (DEGTEREV, ALEXEI)Sep 30, 2018 - Aug 31, 2020
    NIH
    Targeting RIPK3 in Age-Related Inflammation and Injury
    Role: Co-Principal Investigator
    R01AI125362     (CUNY, GREGORY D)Jul 1, 2016 - Jun 30, 2021
    NIH
    IMPDH inhibitors for the treatment of Cryptosporidium infections
    Role: Principal Investigator
    R56AI106743     (CUNY, GREGORY D)Sep 1, 2014 - Aug 31, 2016
    NIH
    Optimizing IMPDH inhibitors for the treatment of cryptosporidiosis
    Role: Principal Investigator
    R41AG042205     (PERRELLA, YUKARI)Sep 1, 2012 - Aug 31, 2013
    NIH
    CSF Tau Biomarker-guided Development of Hsp90 Inhibitors for Alzheimer's Disease
    Role: Co-Principal Investigator
    U01NS074601     (GLICKSMAN, MARCIE A)Jul 1, 2011 - Jun 30, 2016
    NIH
    Small Molecule Modulators of the Glutamate Transporter for Treatment of ALS
    Role: Co-Principal Investigator
    R21NS067497     (GLICKSMAN, MARCIE A)Sep 30, 2009 - Aug 31, 2012
    NIH
    Small molecule probes for elucidating necrotic cell death mechanisms
    Role: Co-Principal Investigator
    U24NS049339     (CUNY, GREGORY D)Jun 15, 2005 - May 31, 2011
    NIH
    National Center for Drug Discovery in Neurodegeneration
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang X, Rosenberg MM, Kim Y, Maltseva N, Cuny GD, Joachimiak A, Kuzmic P, Hedstrom L. Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding. ACS Infect Dis. 2025 Feb 14; 11(2):442-452. PMID: 39879323; PMCID: PMC11841048.
      Citations:    Fields:    
    2. Waldron-Young E, Wijitrmektong W, Choi R, Whitman GR, Hulverson MA, Charania R, Keelaghan A, Li L, Srinual S, Nikhar S, McNamara CW, Love MS, Huerta L, Bakowski MA, Hu M, Van Voorhis WC, Mead JR, Cuny GD. Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium. Mol Biochem Parasitol. 2024 12; 260:111637. PMID: 38901801; PMCID: PMC11629397.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Gautam A, Boyd DF, Nikhar S, Zhang T, Siokas I, Van de Velde LA, Gaevert J, Meliopoulos V, Thapa B, Rodriguez DA, Cai KQ, Yin C, Schnepf D, Beer J, DeAntoneo C, Williams RM, Shubina M, Livingston B, Zhang D, Andrake MD, Lee S, Boda R, Duddupudi AL, Crawford JC, Vogel P, Loch C, Schwemmle M, Fritz LC, Schultz-Cherry S, Green DR, Cuny GD, Thomas PG, Degterev A, Balachandran S. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr; 628(8009):835-843. PMID: 38600381; PMCID: PMC11151938.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    4. Chen H, Lye MF, Gorgulla C, Ficarro SB, Cuny GD, Scott DA, Wu F, Rothlauf PW, Wang X, Fernandez R, Pesola JM, Draga S, Marto JA, Hogle JM, Arthanari H, Coen DM. A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex. PLoS Pathog. 2023 Nov; 19(11):e1011781. PMID: 37976321; PMCID: PMC10691697.
      Citations: 1     Fields:    Translation:HumansCells
    5. Lee S, Love MS, Modukuri R, Chatterjee AK, Huerta L, Lawson AP, McNamara CW, Mead JR, Hedstrom L, Cuny GD. Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition. Bioorg Med Chem Lett. 2023 06 15; 90:129328. PMID: 37196868; PMCID: PMC10290938.
      Citations: 2     Fields:    Translation:HumansAnimals
    6. Pepi MJ, Chacko S, Kopetz N, Boshoff HIM, Cuny GD, Hedstrom L. Nonhydrolyzable d-phenylalanine-benzoxazole derivatives retain antitubercular activity. Bioorg Med Chem Lett. 2023 01 15; 80:129116. PMID: 36572353; PMCID: PMC9885953.
      Citations:    Fields:    Translation:HumansCells
    7. Haile CN, Baker MD, Sanchez SA, Lopez Arteaga CA, Duddupudi AL, Cuny GD, Norton EB, Kosten TR, Kosten TA. An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats. Pharmaceutics. 2022 Oct 26; 14(11). PMID: 36365109; PMCID: PMC9694531.
      Citations: 6     
    8. Pepi MJ, Chacko S, Marqus GM, Singh V, Wang Z, Planck K, Cullinane RT, Meka PN, Gollapalli DR, Ioerger TR, Rhee KY, Cuny GD, Boshoff HIM, Hedstrom L. A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis. ACS Infect Dis. 2022 02 11; 8(2):330-342. PMID: 35015509; PMCID: PMC9558617.
      Citations: 2     Fields:    Translation:Cells
    9. Modi G, Marqus GM, Vippila MR, Gollapalli DR, Kim Y, Manna AC, Chacko S, Maltseva N, Wang X, Cullinane RT, Zhang Y, Kotler JLM, Kuzmic P, Zhang M, Lawson AP, Joachimiak A, Cheung A, Snider BB, Rothstein DM, Cuny GD, Hedstrom L. The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections. ACS Infect Dis. 2021 11 12; 7(11):3062-3076. PMID: 34590817; PMCID: PMC9575405.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Xie L, Li R, Zheng B, Xie Z, Fang X, Wang Y, Cuny GD, Li Z, Lin B, Chen X, Hu M. Development of Rofecoxib-Based Fluorescent Probes and Investigations on Their Solvatochromism, AIE Activity, Mechanochromism, and COX-2-Targeted Bioimaging. Anal Chem. 2021 09 07; 93(35):11991-12000. PMID: 34424685.
      Citations: 1     Fields:    Translation:Humans
    11. Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC. Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry. 2021 08 31; 60(34):2593-2609. PMID: 34411482; PMCID: PMC8410664.
      Citations: 14     Fields:    Translation:HumansCells
    12. Ali G, Cuny GD. 8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities. Molecules. 2021 Jul 27; 26(15). PMID: 34361671; PMCID: PMC8347945.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Ali G, Cuny GD. Syntheses of Gymnothespirolignans B and C and Non-natural Isomer 9-Epi-gymnothespirolignan B. J Org Chem. 2021 08 06; 86(15):10517-10525. PMID: 34282914.
      Citations: 1     Fields:    Translation:Cells
    14. Delanghe T, Huyghe J, Lee S, Priem D, Van Coillie S, Gilbert B, Choi SM, Vandenabeele P, Degterev A, Cuny GD, Dondelinger Y, Bertrand MJM. Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor. Cell Death Dis. 2021 07 14; 12(7):699. PMID: 34262020; PMCID: PMC8280128.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    15. Stone AE, Scheuermann SE, Haile CN, Cuny GD, Velasquez ML, Linhuber JP, Duddupudi AL, Vigliaturo JR, Pravetoni M, Kosten TA, Kosten TR, Norton EB. Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge. NPJ Vaccines. 2021 May 13; 6(1):69. PMID: 33986280; PMCID: PMC8119695.
      Citations: 16     
    16. Xie L, Li R, Zheng B, Xie Z, Fang X, Dai T, Wang X, Li L, Wang L, Cuny GD, Eriksen J, Tu D, Chen Z, Wang X, Chen X, Hu M. One-Step Transformation from Rofecoxib to a COX-2 NIR Probe for Human Cancer Tissue/Organoid Targeted Bioimaging. ACS Appl Bio Mater. 2021 03 15; 4(3):2723-2731. PMID: 35014311.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Nikhar S, Siokas I, Schlicher L, Lee S, Gyrd-Hansen M, Degterev A, Cuny GD. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem. 2021 Apr 05; 215:113252. PMID: 33601309; PMCID: PMC8009825.
      Citations: 3     Fields:    Translation:HumansCells
    18. Lee S, Ku AF, Vippila MR, Wang Y, Zhang M, Wang X, Hedstrom L, Cuny GD. Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorg Med Chem Lett. 2020 12 15; 30(24):127543. PMID: 32931912; PMCID: PMC9511823.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Cuny GD, Degterev A. RIPK protein kinase family: Atypical lives of typical kinases. Semin Cell Dev Biol. 2021 01; 109:96-105. PMID: 32732131; PMCID: PMC8286629.
      Citations: 24     Fields:    Translation:Humans
    20. Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15; 200:112417. PMID: 32505849; PMCID: PMC7338260.
      Citations: 7     Fields:    Translation:HumansCells
    21. Duddupudi AL, Pandey P, Vo H, Welsh CL, Doerksen RJ, Cuny GD. Hypervalent Iodine Mediated Oxidative Cyclization of Acrylamide N-Carbamates to 5,5-Disubstituted Oxazolidine-2,4-diones. J Org Chem. 2020 06 05; 85(11):7549-7557. PMID: 32392063.
      Citations: 1     Fields:    
    22. Ali G, Cuny GD. Synthesis of the Tetracyclic Framework of Polycyclic Spiro Lignan Natural Products. ACS Omega. 2020 Apr 21; 5(15):9007-9012. PMID: 32337465; PMCID: PMC7178799.
      Citations:    
    23. Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B. Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21160-21165. PMID: 31570573; PMCID: PMC6800313.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    24. Kearney SE, Zahor?nszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741. PMID: 30648156; PMCID: PMC6311695.
      Citations: 20     
    25. Jiang JK, Huang X, Shamim K, Patel PR, Lee A, Wang AQ, Nguyen K, Tawa G, Cuny GD, Yu PB, Zheng W, Xu X, Sanderson P, Huang W. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 11 01; 28(20):3356-3362. PMID: 30227946; PMCID: PMC6218249.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    26. Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 09 03; 37(17). PMID: 30026309; PMCID: PMC6120666.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    27. Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents. J Med Chem. 2018 06 14; 61(11):4739-4756. PMID: 29746130; PMCID: PMC6166404.
      Citations: 14     Fields:    Translation:HumansCells
    28. Suebsuwong C, Pinkas DM, Ray SS, Bufton JC, Dai B, Bullock AN, Degterev A, Cuny GD. Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Bioorg Med Chem Lett. 2018 02 15; 28(4):577-583. PMID: 29409752; PMCID: PMC5819902.
      Citations: 8     Fields:    Translation:HumansCells
    29. Ku AF, Cuny GD. Discovery of 7-hydroxyaporphines as conformationally restricted ligands for beta-1 and beta-2 adrenergic receptors. Medchemcomm. 2018 Feb 01; 9(2):353-356. PMID: 30108929; PMCID: PMC6083790.
      Citations: 1     
    30. Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, Mann BJ, Hedstrom L. Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis. Antimicrob Agents Chemother. 2017 10; 61(10). PMID: 28739786; PMCID: PMC5610529.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    31. Cuny GD, Suebsuwong C, Ray SS. Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016). Expert Opin Ther Pat. 2017 Jun; 27(6):677-690. PMID: 28074661.
      Citations: 21     Fields:    Translation:HumansAnimals
    32. Ku AF, Cuny GD. Access to 6a-Alkyl Aporphines: Synthesis of (?)-N-Methylguattescidine. J Org Chem. 2016 10 21; 81(20):10062-10070. PMID: 27689544.
      Citations: 3     Fields:    
    33. Vippila MR, Nikhar S, Gracia AP, Cuny GD. Divergent Approach for the Synthesis of Gombamide A and Derivatives. Org Lett. 2016 09 16; 18(18):4726-9. PMID: 27603447.
      Citations: 1     Fields:    Translation:HumansCells
    34. Vippila MR, Ly PK, Cuny GD. Synthesis and Antiproliferative Activity Evaluation of the Disulfide-Containing Cyclic Peptide Thiochondrilline C and Derivatives. J Nat Prod. 2015 Oct 23; 78(10):2398-404. PMID: 26444379.
      Citations: 2     Fields:    Translation:HumansCells
    35. Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. PLoS One. 2015; 10(10):e0138976. PMID: 26440283; PMCID: PMC4594927.
      Citations: 23     Fields:    Translation:Cells
    36. Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chem Biol. 2015 Sep 17; 22(9):1174-84. PMID: 26320862; PMCID: PMC4579271.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    37. Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):531-8. PMID: 25945705; PMCID: PMC4427161.
      Citations: 4     Fields:    Translation:AnimalsCells
    38. Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2713-9. PMID: 25998502.
      Citations: 6     Fields:    Translation:HumansCells
    39. Ku AF, Cuny GD. Synthetic studies of 7-oxygenated aporphine alkaloids: preparation of (-)-oliveroline, (-)-nornuciferidine, and derivatives. Org Lett. 2015 Mar 06; 17(5):1134-7. PMID: 25710592.
      Citations: 3     Fields:    Translation:Cells
    40. Takahashi K, Kong Q, Lin Y, Stouffer N, Schulte DA, Lai L, Liu Q, Chang LC, Dominguez S, Xing X, Cuny GD, Hodgetts KJ, Glicksman MA, Lin CL. Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. J Exp Med. 2015 Mar 09; 212(3):319-32. PMID: 25711212; PMCID: PMC4354363.
      Citations: 65     Fields:    Translation:AnimalsCells
    41. Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem. 2014 Dec 26; 57(24):10544-50. PMID: 25474504; PMCID: PMC4281095.
      Citations: 14     Fields:    Translation:AnimalsCells
    42. Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett. 2014 Aug 14; 5(8):846-50. PMID: 25147601; PMCID: PMC4137380.
      Citations: 15     
    43. Cuny GD. Foreword: neurodegenerative diseases: challenges and opportunities. Future Med Chem. 2012 Sep; 4(13):1647-9. PMID: 22924500.
      Citations: 13     Fields:    Translation:Humans
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