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Diana S-L. Chow

TitleProfessor
InstitutionUniversity of Houston
DepartmentPharmacological and Pharmaceutical Sciences
Address4800 Calhoun Rd
Houston TX 77004
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    Collapse Research 
    Collapse research activities and funding
    R01CA257842     (LI, CHUN)Aug 1, 2022 - Jun 30, 2026
    NIH
    Pre-IND Development of Polymeric Micelles with Dual Drug Payloads for HCC Therapy
    Role: Co-Principal Investigator

    P20CA221729     (MATZUK, MARTIN M.)Sep 20, 2018 - Aug 31, 2022
    NIH
    2/2: UHCOP-DLDCCC alliance: Cancer drug discovery/development and education
    Role: Co-Principal Investigator

    P20CA221731     (CHOW, DIANA S-L.)Sep 20, 2018 - Aug 31, 2022
    NIH
    1/2: UHCOP-DLDCCC alliance: Cancer drug discovery/development and education
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chow DS, Nguyen A, Park J, Wu L, Toups EG, Harrop JS, Guest JD, Schmitt KM, Aarabi B, Fehlings MG, Boakye M, Grossman RG. Riluzole in Spinal Cord Injury Study (RISCIS)-Pharmacokinetic (PK) Sub-Study: An Analysis of Pharmacokinetics, Pharmacodynamics, and Impact on Axonal Degradation of Riluzole in Patients With Traumatic Cervical Spinal Cord Injury Enrolled in the RISCIS Phase III Randomized Controlled Trial. J Neurotrauma. 2023 09; 40(17-18):1889-1906. PMID: 37130044.
      Citations: 2     Fields:    Translation:Humans
    2. Fehlings MG, Moghaddamjou A, Harrop JS, Stanford R, Ball J, Aarabi B, Freeman BJC, Arnold PM, Guest JD, Kurpad SN, Schuster JM, Nassr A, Schmitt KM, Wilson JR, Brodke DS, Ahmad FU, Yee A, Ray WZ, Brooks NP, Wilson J, Chow DS, Toups EG, Kopjar B. Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial. J Neurotrauma. 2023 09; 40(17-18):1878-1888. PMID: 37279301; PMCID: PMC10460693.
      Citations: 11     Fields:    Translation:HumansPHPublic Health
    3. Bui D, McWilliams LA, Wu L, Zhou H, Wong SJ, You M, Chow DS, Singh R, Hu M. Pharmacokinetic Basis for Using Saliva Matrine Concentrations as a Clinical Compliance Monitoring in Antitumor B Chemoprevention Trials in Humans. Cancers (Basel). 2022 Dec 23; 15(1). PMID: 36612086; PMCID: PMC9817974.
      Citations: 2     
    4. Tu SM, Guo CC, Chow DS, Zacharias NM. Stem Cell Theory of Cancer: Implications for Drug Resistance and Chemosensitivity in Cancer Care. Cancers (Basel). 2022 Mar 18; 14(6). PMID: 35326699; PMCID: PMC8946169.
      Citations: 6     
    5. Nguyen A, Chow DS, Wu L, Teng YA, Sarkar M, Toups EG, Harrop JS, Schmitt KM, Johnson MM, Guest JD, Aarabi B, Shaffrey CI, Boakye M, Frankowski RF, Fehlings MG, Grossman RG. Longitudinal Impact of Acute Spinal Cord Injury on Clinical Pharmacokinetics of Riluzole, a Potential Neuroprotective Agent. J Clin Pharmacol. 2021 09; 61(9):1232-1242. PMID: 33908635; PMCID: PMC8457124.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    6. Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal. 2021 Sep 10; 204:114255. PMID: 34304009.
      Citations: 3     Fields:    Translation:Animals
    7. Agu L, Skiles JL, Masters AR, Renbarger JL, Chow DS. Simultaneous quantification of vincristine and its major M1 metabolite from dried blood spot samples of Kenyan pediatric cancer patients by UPLC-MS/MS. J Pharm Biomed Anal. 2021 Sep 05; 203:114143. PMID: 34111732; PMCID: PMC9441314.
      Citations:    Fields:    Translation:Humans
    8. Gao X, Wu L, Tsai RYL, Ma J, Liu X, Chow DS, Liang D, Xie H. Pharmacokinetic Model Analysis of Supralingual, Oral and Intravenous Deliveries of Mycophenolic Acid. Pharmaceutics. 2021 Apr 17; 13(4). PMID: 33920640; PMCID: PMC8072905.
      Citations: 2     
    9. Lincha VR, Hsiao CH, Zhao J, Li C, Chow DS. Sensitive and rapid UHPLC-MS/MS assay for simultaneous quantifications of calcipotriol and paclitaxel in rat whole blood and plasma samples. J Pharm Biomed Anal. 2021 Jan 05; 192:113685. PMID: 33099115.
      Citations: 2     Fields:    Translation:Animals
    10. Sheth RA, Wen X, Li J, Melancon MP, Ji X, Wang YA, Hsiao CH, Chow DS, Whitley EM, Li C, Gupta S. Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy. Cancer Nanotechnol. 2020; 11(1). PMID: 34335988; PMCID: PMC8323745.
      Citations: 8     
    11. Chityala PK, Wu L, Chow DS, Ghose R. Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model. Chem Biol Interact. 2020 Jan 25; 316:108933. PMID: 31870839.
      Citations: 3     Fields:    Translation:Animals
    12. Shi S, Li T, Wen X, Wu SY, Xiong C, Zhao J, Lincha VR, Chow DS, Liu Y, Sood AK, Li C. Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention. Bioconjug Chem. 2019 10 16; 30(10):2675-2683. PMID: 31560538; PMCID: PMC6947533.
      Citations: 36     Fields:    Translation:AnimalsCells
    13. El-Zailik A, Cheung LK, Wang Y, Sherman V, Chow DS. Correction to: Longitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins. Obes Surg. 2019 Aug; 29(8):2584. PMID: 31037595.
      Citations:    Fields:    
    14. El-Zailik A, Cheung LK, Wang Y, Sherman V, Chow DS. Longitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins. Obes Surg. 2019 08; 29(8):2571-2583. PMID: 31004269; PMCID: PMC6660378.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    15. Hsiao CH, Zhao J, Gao S, Farhan N, Wang Y, Li C, Chow DS. Development and validation of a rapid and sensitive UPLC-MS/MS assay for simultaneous quantification of paclitaxel and cyclopamine in mouse whole blood and tissue samples. Biomed Chromatogr. 2019 Sep; 33(9):e4518. PMID: 30805953.
      Citations: 1     Fields:    Translation:Animals
    16. Dong D, Hsiao CH, Giovanella BC, Wang Y, Chow DS, Li Z. Sustained delivery of a camptothecin prodrug - CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity. Int J Nanomedicine. 2019; 14:3799-3817. PMID: 31213802; PMCID: PMC6540077.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Lin CH, Wu MR, Huang WJ, Chow DS, Hsiao G, Cheng YW. Low-Luminance Blue Light-Enhanced Phototoxicity in A2E-Laden RPE Cell Cultures and Rats. Int J Mol Sci. 2019 Apr 11; 20(7). PMID: 30979028; PMCID: PMC6480556.
      Citations: 13     Fields:    Translation:AnimalsCells
    18. Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C. Integrin av?3-Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjug Chem. 2018 12 19; 29(12):4062-4071. PMID: 30404438; PMCID: PMC6693325.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    19. El-Zailik A, Cheung LK, Wang Y, Sherman V, Chow DS. Simultaneous LC-MS/MS analysis of simvastatin, atorvastatin, rosuvastatin and their active metabolites for plasma samples of obese patients underwent gastric bypass surgery. J Pharm Biomed Anal. 2019 Feb 05; 164:258-267. PMID: 30396053; PMCID: PMC6298799.
      Citations: 6     Fields:    Translation:Humans
    20. Zhao J, Xiao Z, Li T, Chen H, Yuan Y, Wang YA, Hsiao CH, Chow DS, Overwijk WW, Li C. Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer. ACS Nano. 2018 10 23; 12(10):9881-9893. PMID: 30231203; PMCID: PMC6245606.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    21. Sarkar M, Grossman RG, Toups EG, Chow DS. Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats. Eur J Pharm Sci. 2018 Dec 01; 125:1-10. PMID: 30201516.
      Citations: 3     Fields:    Translation:Animals
    22. Kim YJ, Tu Y, Chow DS. Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay for simultaneous quantifications of CZ48, lactone-stabilized camptothecin, and camptothecin and their pharmacokinetic and biliary evaluations in rats. J Pharm Biomed Anal. 2018 Nov 30; 161:122-128. PMID: 30149187.
      Citations:    Fields:    Translation:Animals
    23. Belkacemi L, Atkins JL, Yang LU, Gadgil P, Sater AK, Chow DS, Bose RN, Zhang SX. Phosphaplatin Anti-tumor Effect Enhanced by Liposomes Partly via an Up-regulation of PEDF in Breast Cancer. Anticancer Res. 2018 02; 38(2):623-646. PMID: 29374685.
      Citations: 3     Fields:    Translation:AnimalsCells
    24. Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials. 2018 03; 159:215-228. PMID: 29331808; PMCID: PMC6203960.
      Citations: 46     Fields:    Translation:AnimalsCells
    25. Sarkar M, Grossman RG, Toups EG, Chow DS. UPLC-MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients. J Pharm Biomed Anal. 2017 Nov 30; 146:334-340. PMID: 28917164.
      Citations: 3     Fields:    Translation:Humans
    26. Zhang D, Chow DS. Clinical Pharmacokinetics of Mycophenolic Acid in Hematopoietic Stem Cell Transplantation Recipients. Eur J Drug Metab Pharmacokinet. 2017 Apr; 42(2):183-189. PMID: 27677732.
      Citations: 11     Fields:    Translation:Humans
    27. Zhang D, Renbarger JL, Chow DS. Pharmacokinetic Variability of Mycophenolic Acid in Pediatric and Adult Patients With Hematopoietic Stem Cell Transplantation. J Clin Pharmacol. 2016 11; 56(11):1378-1386. PMID: 27060685.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    28. Farhan N, Fitzpatrick S, Shim YM, Paige M, Chow DS. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation. J Pharm Biomed Anal. 2016 Sep 05; 128:46-52. PMID: 27232150.
      Citations:    Fields:    Translation:Animals
    29. Zhang D, Chow DS, Renbarger JL. Simultaneous quantification of mycophenolic acid and its glucuronide metabolites in human plasma by an UPLC-MS/MS assay. Biomed Chromatogr. 2016 Oct; 30(10):1648-55. PMID: 27061819.
      Citations: 2     Fields:    Translation:Humans
    30. Manchandani P, Zhou J, Ledesma KR, Truong LD, Chow DS, Eriksen JL, Tam VH. Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model. Antimicrob Agents Chemother. 2016 Feb; 60(2):1029-34. PMID: 26643340; PMCID: PMC4750689.
      Citations: 31     Fields:    Translation:Animals
    31. Zhang D, Wu L, Chow DS, Tam VH, Rios DR. Quantitative determination of dopamine in human plasma by a highly sensitive LC-MS/MS assay: Application in preterm neonates. J Pharm Biomed Anal. 2016 Jan 05; 117:227-31. PMID: 26372947.
      Citations: 7     Fields:    Translation:Humans
    32. Abodakpi H, Gohlke J, Chang KT, Chow DS, Tam VH. Analytical and functional determination of polymyxin B protein binding in serum. Antimicrob Agents Chemother. 2015 Nov; 59(11):7121-3. PMID: 26324262; PMCID: PMC4604353.
      Citations: 11     Fields:    Translation:HumansCells
    33. Wu L, Boyd JL, Daniels V, Wang Z, Chow DS, Putcha L. Dose escalation pharmacokinetics of intranasal scopolamine gel formulation. J Clin Pharmacol. 2015 Feb; 55(2):195-203. PMID: 25187210.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    34. Zhang D, Rios DR, Tam VH, Chow DS. Development and validation of a highly sensitive LC-MS/MS assay for the quantification of arginine vasopressin in human plasma and urine: Application in preterm neonates and child. J Pharm Biomed Anal. 2014 Oct; 99:67-73. PMID: 25072843.
      Citations: 4     Fields:    Translation:Humans
    35. He J, Abdelraouf K, Ledesma KR, Chow DS, Tam VH. Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model. Int J Antimicrob Agents. 2013 Dec; 42(6):559-64. PMID: 24016799; PMCID: PMC3849129.
      Citations: 16     Fields:    Translation:AnimalsCells
    36. He J, Gao S, Hu M, Chow DS, Tam VH. A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. J Antimicrob Chemother. 2013 May; 68(5):1104-10. PMID: 23341128; PMCID: PMC3625435.
      Citations: 20     Fields:    Translation:Animals
    37. Chow DS, Teng Y, Toups EG, Aarabi B, Harrop JS, Shaffrey CI, Johnson MM, Boakye M, Frankowski RF, Fehlings MG, Grossman RG. Pharmacology of riluzole in acute spinal cord injury. J Neurosurg Spine. 2012 Sep; 17(1 Suppl):129-40. PMID: 22985379.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    38. Dong D, Wu B, Chow D, Hu M. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012 May; 44(2):192-208. PMID: 22251142.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    39. He J, Figueroa DA, Lim TP, Chow DS, Tam VH. Stability of polymyxin B sulfate diluted in 0.9% sodium chloride injection and stored at 4 or 25 degrees C. Am J Health Syst Pharm. 2010 Jul 15; 67(14):1191-4. PMID: 20592326.
      Citations: 5     Fields:    Translation:CellsPHPublic Health
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