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Seema Khurana

TitleAssociate Professor
InstitutionUniversity of Houston
DepartmentBiology and Biochemistry
Address4800 Calhoun Rd
Houston TX 77004
Phone713-743-2705
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    Collapse Research 
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    R01DK117476     (KHURANA, SEEMA)Sep 20, 2018 - Aug 31, 2023
    NIH
    Changes in actin dynamics regulated by villin and gesolin are determinants of cell fate and may be key to gastrointestinal inflammatory disease
    Role: Principal Investigator

    R01DK098120     (KHURANA, SEEMA)Sep 18, 2013 - May 31, 2019
    NIH
    Epithelial mesenchymal transition in gastrointestinal homeostasis and disease
    Role: Principal Investigator

    R01DK081408     (KHURANA, SEEMA)Aug 20, 2009 - Jul 31, 2012
    NIH
    Regulation of epithelial cell homeostasis by actin microfilaments
    Role: Principal Investigator

    R01DK065006     (KHURANA, SEEMA)Apr 1, 2004 - Mar 31, 2010
    NIH
    Regulation of epithelial cell motility by villin
    Role: Principal Investigator

    R01DK054755     (KHURANA, SEEMA)May 1, 2000 - Apr 30, 2011
    NIH
    Role of villin in epithelial cell signal transduction
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Esmaeilniakooshkghazi A, Pham E, George SP, Ahrorov A, Villagomez FR, Byington M, Mukhopadhyay S, Patnaik S, Conrad JC, Naik M, Ravi S, Tebbutt N, Mooi J, Reehorst CM, Mariadason JM, Khurana S. In colon cancer cells fascin1 regulates adherens junction remodeling. FASEB J. 2023 03; 37(3):e22786. PMID: 36786724.
      Citations: 1     Fields:    Translation:HumansCells
    2. George SP, Esmaeilniakooshkghazi A, Roy S, Khurana S. F-actin-bundling sites are conserved in proteins with villin-type headpiece domains. Mol Biol Cell. 2020 08 01; 31(17):1857-1866. PMID: 32520642; PMCID: PMC7525818.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    3. Esmaeilniakooshkghazi A, George SP, Biswas R, Khurana S. Mouse intestinal tuft cells express advillin but not villin. Sci Rep. 2020 06 01; 10(1):8877. PMID: 32483224; PMCID: PMC7264147.
      Citations: 12     Fields:    Translation:AnimalsCells
    4. Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George SP, Ahrorov A, Hou JK, Herron AJ, Sesaki H, Khurana S. Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation. Gastroenterology. 2018 04; 154(5):1405-1420.e2. PMID: 29274870; PMCID: PMC7808315.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    5. Rao J, Ashraf S, Tan W, van der Ven AT, Gee HY, Braun DA, Feh?r K, George SP, Esmaeilniakooshkghazi A, Choi WI, Jobst-Schwan T, Schneider R, Schmidt JM, Widmeier E, Warejko JK, Hermle T, Schapiro D, Lovric S, Shril S, Daga A, Nayir A, Shenoy M, Tse Y, Bald M, Helmchen U, Mir S, Berdeli A, Kari JA, El Desoky S, Soliman NA, Bagga A, Mane S, Jairajpuri MA, Lifton RP, Khurana S, Martins JC, Hildebrandt F. Advillin acts upstream of phospholipase C ?1 in steroid-resistant nephrotic syndrome. J Clin Invest. 2017 12 01; 127(12):4257-4269. PMID: 29058690; PMCID: PMC5707164.
      Citations: 23     Fields:    Translation:HumansCells
    6. Mikami M, Zhang Y, Danielsson J, Joell T, Yong HM, Townsend E, Khurana S, An SS, Emala CW. Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin. Am J Respir Cell Mol Biol. 2017 05; 56(5):628-636. PMID: 28118027; PMCID: PMC5449493.
      Citations: 12     Fields:    Translation:AnimalsCells
    7. Wang Y, George SP, Roy S, Pham E, Esmaeilniakooshkghazi A, Khurana S. Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis. Sci Rep. 2016 10 21; 6:35491. PMID: 27765954; PMCID: PMC5073230.
      Citations: 15     Fields:    Translation:AnimalsCells
    8. Patnaik S, George SP, Pham E, Roy S, Singh K, Mariadason JM, Khurana S. By moonlighting in the nucleus, villin regulates epithelial plasticity. Mol Biol Cell. 2016 Feb 01; 27(3):535-48. PMID: 26658611; PMCID: PMC4751603.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    9. George SP, Chen H, Conrad JC, Khurana S. Regulation of directional cell migration by membrane-induced actin bundling. J Cell Sci. 2013 Jan 01; 126(Pt 1):312-26. PMID: 23132923; PMCID: PMC3603521.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    10. Khurana S, George SP. The role of actin bundling proteins in the assembly of filopodia in epithelial cells. Cell Adh Migr. 2011 Sep-Oct; 5(5):409-20. PMID: 21975550; PMCID: PMC3218608.
      Citations: 30     Fields:    Translation:HumansCells
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