Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
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| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
|
| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
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This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Dual optical elastography detects TGF-? -induced alterations in the biomechanical properties of skin scaffolds. J Biomed Opt. 2024 Sep; 29(9):095002.
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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-ß Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail. 2023 Dec; 16(12):e010351.
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CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity. Leukemia. 2019 Nov; 33(11):2640-2653.
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The p38 mitogen-activated protein kinase pathway negatively regulates Ca2+-activated K+ channel trafficking in developing parasympathetic neurons. J Neurochem. 2005 Jul; 94(2):367-79.
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Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. J Neurophysiol. 2005 Mar; 93(3):1174-82.
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Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons. Brain Res. 2003 Aug 22; 982(1):119-24.
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Expression of K(Ca) channels in identified populations of developing vertebrate neurons: role of neurotrophic factors and activity. J Physiol Paris. 2003 Jan; 97(1):49-58.
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Developmental regulation of neuronal K(Ca) channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion. J Neurophysiol. 2002 Aug; 88(2):954-64.