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Bin Guo

TitleAssistant Professor
InstitutionUniversity of Houston
DepartmentPharmacological and Pharmaceutical Sciences
Address4800 Calhoun Rd
Houston TX 77004
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    R01CA293945     (GUO, PEIXUAN)Jul 2, 2024 - Jun 30, 2029
    NIH
    Mechanism and approach to inactivate mutant KRAS of lung metastatic colon cancer by RNA-ligand-displaying exosome to co-deliver dCas9--gRNA ribonucleoprotein complex and KRAS siRNA
    Role: Principal Investigator
    R01GM114080     (MALLIK, SANKU)Sep 5, 2015 - Aug 31, 2024
    NIH
    Echogenic polymersomes for triggered contents release
    Role: Co-Principal Investigator
    R01CA186100     (GUO, BIN)May 19, 2015 - Apr 30, 2021
    NIH
    RNA Therapeutics for Targeted Treatment of Colon Cancer
    Role: Principal Investigator
    R03CA130062     (GUO, BIN)Jul 2, 2008 - Jun 30, 2011
    NIH
    Chemoprevention of Familial Adenomatous Polyposis by a Combination of 3,3?-Diind
    Role: Principal Investigator
    R21CA111765     (GUO, BIN)Sep 1, 2005 - Aug 31, 2008
    NIH
    Mechanisms of Bax Activation in Apoptosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu M, Sarkar C, Guo B. Regulation of Cancer Metastasis by PAK2. Int J Mol Sci. 2024 Dec 15; 25(24). PMID: 39769207; PMCID: PMC11676821.
      Citations:    Fields:    Translation:HumansAnimals
    2. Lu J, Zhang Y, Yan C, Liu J, Qi D, Zhou Y, Wang Q, Yang J, Jiang J, Wu B, Yang M, Zhang W, Zhang X, Shi X, Zhang Y, Liu K, Liang Y, Wang C, Yang H, Gao Y, Sun Y, Ke R, Huang JH, Wu M, Wang H, Li C, Zhou S, Guo B, Wu E, Zhang G. TClC effectively suppresses the growth and metastasis of NSCLC via polypharmacology. Bioact Mater. 2025 Mar; 45:567-583. PMID: 39759535; PMCID: PMC11700266.
      Citations:    
    3. Amina SJ, Azam T, Dagher F, Guo B. A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics. Expert Opin Drug Deliv. 2024 Jan-Jun; 21(1):45-70. PMID: 38226932.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Cho KB, Shukla SP, Kannan M, Zhang H, Amina SJ, Zhou S, Chen Y, Molligan JF, Taneja V, Mohan C, Udugamasooriya DG, Guo B. A peptoid interleukin-15 receptor antagonist suppresses inflammation and arthritis in mice. Clin Transl Immunology. 2022; 11(11):e1432. PMID: 36439637; PMCID: PMC9686008.
      Citations: 1     
    5. Shukla SP, Raymond A, Rustagi V, Kedika SR, Tran O, Wang L, Guo B, Udugamasooriya DG. A novel peptidomimetic therapeutic for selective suppression of lung cancer stem cells over non-stem cancer cells. Bioorg Chem. 2021 11; 116:105340. PMID: 34530236; PMCID: PMC8588801.
      Citations: 2     Fields:    Translation:HumansCells
    6. Shukla SP, Cho KB, Rustagi V, Gao X, Fu X, Zhang SX, Guo B, Udugamasooriya DG. "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry. Int J Mol Sci. 2021 Aug 20; 22(16). PMID: 34445669; PMCID: PMC8396575.
      Citations: 4     Fields:    Translation:HumansCells
    7. Baviskar T, Momin M, Liu J, Guo B, Bhatt L. Target Genetic Abnormalities for the Treatment of Colon Cancer and Its Progression to Metastasis. Curr Drug Targets. 2021; 22(7):722-733. PMID: 33213339.
      Citations: 3     Fields:    Translation:Humans
    8. Amina SJ, Guo B. A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle. Int J Nanomedicine. 2020; 15:9823-9857. PMID: 33324054; PMCID: PMC7732174.
      Citations: 115     Fields:    Translation:Humans
    9. Liu J, Sun M, Cho KB, Gao X, Guo B. A CRISPR-Cas9 repressor for epigenetic silencing of KRAS. Pharmacol Res. 2021 02; 164:105304. PMID: 33202255; PMCID: PMC8422974.
      Citations: 11     Fields:    Translation:HumansCells
    10. Gao X, Liu J, Cho KB, Kedika S, Guo B. Chemopreventive Agent 3,3'-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells. Int J Mol Sci. 2020 Jun 30; 21(13). PMID: 32629830; PMCID: PMC7370074.
      Citations: 7     Fields:    Translation:HumansCells
    11. Wang L, Zhou S, Guo B. Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2. Int J Mol Sci. 2020 Mar 27; 21(7). PMID: 32230936; PMCID: PMC7177268.
      Citations: 16     Fields:    Translation:HumansCells
    12. Liu J, Guo B. RNA-based therapeutics for colorectal cancer: Updates and future directions. Pharmacol Res. 2020 02; 152:104550. PMID: 31866285; PMCID: PMC7027327.
      Citations: 19     Fields:    Translation:HumansAnimals
    13. Wang L, Cho KB, Li Y, Tao G, Xie Z, Guo B. Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer. Int J Mol Sci. 2019 Nov 16; 20(22). PMID: 31744051; PMCID: PMC6888455.
      Citations: 303     Fields:    Translation:Humans
    14. Zheng Z, Li Z, Xu C, Guo B, Guo P. Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping. J Control Release. 2019 Oct; 311-312:43-49. PMID: 31446085; PMCID: PMC6874920.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    15. Pi F, Binzel DW, Lee TJ, Li Z, Sun M, Rychahou P, Li H, Haque F, Wang S, Croce CM, Guo B, Evers BM, Guo P. Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression. Nat Nanotechnol. 2018 Jan; 13(1):82-89. PMID: 29230043; PMCID: PMC5762263.
      Citations: 192     Fields:    Translation:HumansAnimalsCells
    16. Sun M, Guo B. Vitamin D and the Epigenetic Machinery in Colon Cancer. Curr Med Chem. 2017; 24(9):888-897. PMID: 27855629.
      Citations: 2     Fields:    Translation:HumansCells
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