"Orphan Nuclear Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
| Descriptor ID |
D057093
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| MeSH Number(s) |
D12.776.260.643 D12.776.826.209 D12.776.930.645
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Orphan Nuclear Receptors".
Below are MeSH descriptors whose meaning is more specific than "Orphan Nuclear Receptors".
- Orphan Nuclear Receptors
- COUP Transcription Factors
- Nuclear Receptor Subfamily 1, Group D, Member 1
- Nuclear Receptor Subfamily 1, Group F, Member 1
- Nuclear Receptor Subfamily 1, Group F, Member 2
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Nuclear Receptor Subfamily 2, Group C, Member 1
- Nuclear Receptor Subfamily 2, Group C, Member 2
- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nuclear Receptor Subfamily 4, Group A, Member 3
- Nuclear Receptor Subfamily 6, Group A, Member 1
- Receptors, Aryl Hydrocarbon
This graph shows the total number of publications written about "Orphan Nuclear Receptors" by people in this website by year, and whether "Orphan Nuclear Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 3 | 0 | 3 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Orphan Nuclear Receptors" by people in Profiles.
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Liver X Receptor Inverse Agonist GAC0001E5 Impedes Glutaminolysis and Disrupts Redox Homeostasis in Breast Cancer Cells. Biomolecules. 2023 02 10; 13(2).
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Liver X receptor ? controls thyroid hormone feedback in the brain and regulates browning of subcutaneous white adipose tissue. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14006-11.
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The emerging roles of liver X receptors and their ligands in cancer. Expert Opin Ther Targets. 2016; 20(1):61-71.
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Targeting liver X receptors in cancer therapeutics. Nat Rev Cancer. 2015 Apr; 15(4):216-24.
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Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells. PLoS One. 2014; 9(9):e106289.
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Action mechanisms of Liver X Receptors. Biochem Biophys Res Commun. 2014 Apr 11; 446(3):647-50.
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Liver X receptor ? protects dopaminergic neurons in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13112-7.
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Anxiety in liver X receptor ? knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7493-8.
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Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):12305-10.